NS-638
目录号 : GC30997
An N- and L-type calcium channel inhibitor
Cas No.:150493-34-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
NS 638 is an inhibitor of the N-type voltage-gated calcium channel Cav2.2 and CNS L-type calcium channels.1 It inhibits potassium-induced calcium uptake in chick cortical synaptosomes (IC50 = 3.4 ?M) and AMPA-induced GABA release from primary chick cortical neurons (IC50 = 4.3 ?M), effects that can be blocked by the N-type calcium channel inhibitor ω-conotoxin GVIA but not the L-type calcium channel inhibitor nifedipine . It also inhibits potassium-induced calcium level increases in primary chick cerebellar granule cells (IC50 = 3.4 ?M), an effect that can be blocked by nifedipine but not ω-conotoxin GVIA. NS 638 (50 mg/kg) reduces infarct volume in a mouse model of focal ischemia induced by middle cerebral artery occlusion (MCAO) but not in a gerbil model of global ischemia induced by bilateral carotid artery occlusion (BCAO).
1.M?ller, A., Christophersen, P., Drejer, J., et al.Pharmacological profile and anti-ischemic properties of the Ca2+-channel blocker NS-638Neurol. Res.17(5)353-360(1995)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0701 mL | 15.3506 mL | 30.7012 mL |
| 5 mM | 0.614 mL | 3.0701 mL | 6.1402 mL |
| 10 mM | 0.307 mL | 1.5351 mL | 3.0701 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。