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NSC95682 (6-Bromo-2-hydroxy-3-methoxybenzaldehyde) Sale

(Synonyms: 6-溴-2-羟基于-甲氧基苯甲醛,NSC95682) 目录号 : GC34111

6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an IRE-1α inhibitor with an IC50 of 0.08 μM.

NSC95682 (6-Bromo-2-hydroxy-3-methoxybenzaldehyde) Chemical Structure

Cas No.:20035-41-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥589.00
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50mg
¥536.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an IRE-1α inhibitor with an IC50 of 0.08 μM.

[1] John Bruce Patterson, et al. WO2008154484A1.

Chemical Properties

Cas No. 20035-41-0 SDF
别名 6-溴-2-羟基于-甲氧基苯甲醛,NSC95682
Canonical SMILES O=CC1=C(C(OC)=CC=C1Br)O
分子式 C8H7BrO3 分子量 231.04
溶解度 DMSO : 113 mg/mL (489.09 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 4.3283 mL 21.6413 mL 43.2825 mL
5 mM 0.8657 mL 4.3283 mL 8.6565 mL
10 mM 0.4328 mL 2.1641 mL 4.3283 mL
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Research Update

First total synthesis of antihypertensive natural products S-(+)-XJP and R-(-)-XJP

The first asymmetric total synthesis of antihypertensive natural products S-(+)-XJP and R-(-)-XJP has been achieved in 8 steps starting from commercially available 6-bromo-2-hydroxy-3-methoxybenzaldehyde. Key steps included intramolecular Heck reaction and oxidative ozonolysis reaction with the retention of stereochemistry. A latent functionality strategy was implemented to circumvent the racemization in this endeavor. The protocol described here provided a fast and easily accessible synthetic method to obtain optically pure isochroman-4-one derivatives. Furthermore, the in vivo antihypertensive effects of (±)-XJP, S-(+)-XJP and R-(-)-XJP were investigated on spontaneously hypertensive rats. The obtained results could provide valuable information to identify a promising lead for further chemical modification research.

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids

In this study, we report the synthesis, antibacterial and anticancer evaluation of 38 novel phenanthridines that were designed as analogs of the benzo[c]phenanthridine alkaloids. The prepared phenanthridines differ from the benzo[c]phenanthridines in the absence of a benzene A-ring. All novel compounds were prepared from 6-bromo-2-hydroxy-3-methoxybenzaldehyde in several synthetic steps through reduction of Schiff bases and accomplished by radical cyclization. Twelve derivatives showed high antibacterial activity against Bacillussubtilis, Micrococcusluteus and/or Mycobacteriumvaccae at single digit micromolar concentrations. Some compounds also displayed cytotoxicity against the K-562 and MCF-7 cancer cell lines at as low as single digit micromolar concentrations and were more potent than chelerythrine and sanguinarine. The active compounds caused cell-cycle arrest in cancer cells, increased levels of p53 protein and caused apoptosis-specific fragmentation of PARP-1. Biological activity was connected especially with the presence of the N-methyl quaternary nitrogen and 7-benzyloxy substitution (compounds 7i, 7j, 7k, and 7l) of phenanthridine.