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Nullscript

目录号 : GC13925

A negative control for scriptaid

Nullscript Chemical Structure

Cas No.:300816-11-9

规格 价格 库存 购买数量
1mg
¥952.00
现货
5mg
¥4,267.00
现货
10mg
¥7,550.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Nullscript is an HDAC inhibitor.

Histone deacetylase inhibitors (HDIs) have been used in psychiatry and neurology as mood stabilizers and anti-epileptics, such as valproic acid. Recently, HDIs are being studied as a mitigator or treatment for neurodegenerative diseases. Moreover, there has been an effort to develop HDIs for cancer therapy.

In vitro: Nullscript, a close analog of scriptaid, was found to be inactive in transcriptional facilitation at corresponding concentrations, which confirmed a minimal requirement for the length of the linker chain expected for this class of HDAC inhibitors. In addition, nullscript was not able to induce the p6SBE-luc reporter construct, which was identified from the library using ChemFinder by its structural similarity to scriptaid [1].

In vivo: A standard in vivo model of cardiac I/RWe was utilized to examine the in vivo consequences of HDAC inhibition in the intact heart. Results showed that the treatment with scriptaid led to a nearly identical effect when compared to nullscript, with a 46.8% reduction in infarct size. Such results strongly suggested that in murine models, HDACIs could reverse the induction of ischemia-induced HDAC activity and reduced myocardial infarct size by more than 50% [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] G.  H. Su, T. A. Sohn, B. Ryu, et al. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Research 60, 3137-3142 (2000).
[2] Anne Granger et al.  Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J. 2008 Oct; 22(10): 3549–3560.

Chemical Properties

Cas No. 300816-11-9 SDF
化学名 N-hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-butanamide
Canonical SMILES O=C(C1=CC=CC2=CC=CC3=C12)N(CCCC(NO)=O)C3=O
分子式 C16H14N2O4 分子量 298.3
溶解度 ≤2mg/ml in DMSO;2mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.3523 mL 16.7616 mL 33.5233 mL
5 mM 0.6705 mL 3.3523 mL 6.7047 mL
10 mM 0.3352 mL 1.6762 mL 3.3523 mL
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