O-glycosylation-IN-1
(Synonyms: 苄基-2-乙酰胺基-2-脱氧-Α-D-吡喃半乳糖苷) 目录号 : GC39720
An inhibitor of mucin synthesis
Cas No.:3554-93-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside (benzyl-α-GalNAc) is an inhibitor of mucin synthesis.1,2,3 It inhibits glucosamine labeling, a marker of mucin synthesis, in Caco-2, HT-29, and T84 colon cancer cells when used at a concentration of 2 mM.1 Benzyl-α-GalNAc (0.4, 0.6, and 0.8 mg/ml) enhances cell death induced by 5-fluorouracil in Capan-1 and HPAF-II cells.2 LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells.3
1.Niv, Y., Byrd, J.C., Ho, S.B., et al.Mucin synthesis and secretion in relation to spontaneous differentiation of colon cancer cells in vitroInt. J. Cancer50(1)147-152(1992) 2.Kalra, A.V., and Campbell, R.B.Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: Overcoming cellular barriers for therapeutic gainBr. J. Cancer97(7)910-918(2007) 3.Bresalier, R.S., Niv, Y., Byrd, J.C., et al.Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasisJ. Clin. Invest.87(3)1037-1045(1991)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.212 mL | 16.0601 mL | 32.1203 mL |
| 5 mM | 0.6424 mL | 3.212 mL | 6.4241 mL |
| 10 mM | 0.3212 mL | 1.606 mL | 3.212 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。