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O4I1 Sale

(Synonyms: 2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈) 目录号 : GC12499

An inducer of Oct3/4

O4I1 Chemical Structure

Cas No.:175135-47-4

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产品描述

O4I1 is a potent Oct3/4 inducer implicated in promoting the expression and stabilization of Oct3/4. O4I1 can enhance the transcriptional activity of Oct3/4 in a variety of human somatic cells. Oct3/4, also known as POU5F1 and Oct4, is a transcription factor which is essential for self-renewal and pluripotency of embryonic stem cells. Oct3/4 is specifically expressed in the ES cells, epiblast, preimplantation embryos, and germ cells, et al [1].

When treated the synthesized cDNA from RNA isolated from the HEK293 cells with 10 µM and 20 µM O4I1 for 72 hrs, the Oct3/4 mRNA levels increased about 2.5- and 4-fold respectively. In human adult primary fibroblast (HF) and human neonatal foreskin fibroblast (HFF) cell lines, treatment with 10 µM O4I1 increased the gene and protein expression level of Oct3/4 after 72 hrs incubation in HF cells and 7 days in HFF cells. The derivatives of O4I1 such as compound 2, showed a time-dependent activation of Oct3/4 and markedly elevated the efficiency of Oct3/4 induction [1].

Reference:
[1].Cheng X, Dimou E, Alborzinia H, et al.  Identification of 2-[4-[(4-Methoxyphenyl) methoxy]-phenyl] acetonitrile and Derivatives as Potent Oct3/4 Inducers[J]. Journal of medicinal chemistry, 2015, 58(12): 4976-4983.

Chemical Properties

Cas No. 175135-47-4 SDF
别名 2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈
化学名 2-(4-((4-methoxybenzyl)oxy)phenyl)acetonitrile
Canonical SMILES COC1=CC=C(COC2=CC=C(CC#N)C=C2)C=C1
分子式 C16H15NO2 分子量 253.3
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml,Ethanol: slightly 储存条件 Store at -20°C
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1 mM 3.9479 mL 19.7394 mL 39.4789 mL
5 mM 0.7896 mL 3.9479 mL 7.8958 mL
10 mM 0.3948 mL 1.9739 mL 3.9479 mL
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