Ochratoxin B-13C20
(Synonyms: OTB-13C20) 目录号 : GC91764Ochratoxin B-13C20 (OTB-13C20) is intended for use as an internal standard for the quantification of ochratoxin B by GC- or LC-MS.
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Ochratoxin B-13C20 (OTB-13C20) is intended for use as an internal standard for the quantification of ochratoxin B by GC- or LC-MS. OTB is a mycotoxin that has been found in Aspergillus and is a non-chlorinated derivative of OTA .[1] Unlike OTA, OTB is not genotoxic to HepG2 cells but does inhibit cell division when used at concentrations ranging from 1 to 25 µg/ml.[2] It induces mortality (LC50 = 700 nM) and craniofacial malformations (EC50 = 200 nM) in Xenopus embryos.[3] OTB has been found in poultry feed.[4]
References:
[1].Varga, J., Kevei, E., Rinyu, E., et al.Ochratoxin production by Aspergillus speciesAppl. Environ. Microbiol.62(12)4461-4464(1996).
[2].Knasmüller, S., Cavin, C., Chakraborty, A., et al.Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: Implications for risk assessmentNutr. Cancer50(2)190-197(2004).
[3].O'Brien, E., Prietz, A., and Dietrich, D.R.Investigation of the teratogenic potential of ochratoxin A and B using the FETAX systemBirth Defects Res. B Dev. Reprod. Toxicol.74(5)417-423(2005).
[4].Ezekiel, C.N., Bandyopadhyay, R., Sulyok, M., et al.Fungal and bacterial metabolites in commercial poultry feed from NigeriaFood Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess.29(8)1288-1299(2012).
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5694 mL | 12.8469 mL | 25.6937 mL |
| 5 mM | 0.5139 mL | 2.5694 mL | 5.1387 mL |
| 10 mM | 0.2569 mL | 1.2847 mL | 2.5694 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。