Ochratoxin C-13C20
(Synonyms: Ochratoxin A-13C20 ethyl ester,OTC-13C20,OTA-13C20 ethyl ester) 目录号 : GC91779Ochratoxin C-13C20 (OTC-13C20) is intended for use as an internal standard for the quantification of ochratoxin C by GC- or LC-MS.
Sample solution is provided at 25 µL, 10mM.
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Ochratoxin C-13C20 (OTC-13C20) is intended for use as an internal standard for the quantification of ochratoxin C by GC- or LC-MS. OTC is a mycotoxin that has been found in Aspergillus and is an active metabolite of OTA .[1],[2] It is formed from OTA by gut microbiota, however, OTA can also be formed from OTC in vivo.2,3 OTC inhibits the proliferation and differentiation of THP-1 monocytes (IC50s = 126 and 91 ng/ml, respectively) and induces apoptosis in the same cells when used at concentrations of 100 or 1,000 ng/ml.[1] It induces mortality in zebrafish embryos (LC50 = 0.32 nM).[4] OTC has been found in red wine.[5]
References:
[1].Müller, G., Rosner, H., Rohrmann, B., et al.Effects of the mycotoxin ochratoxin A and some of its metabolites on the human cell line THP-1Toxicology184(1)69-82(2003).
[2].Galtier, P., and Alvinerie, M.In vitro transformation of ochratoxin A by animal microbioal florasAnn. Rech. Vet.7(1)91-98(1976).
[3].Fuchs, R., Hult, K., Peraica, M., et al.Conversion of ochratoxin C into ochratoxin A in vivoAppl. Environ. Microbiol.48(1)41-42(1984).
[4].Csenki, Z., Garai, E., Faisal, Z., et al.The individual and combined effects of ochratoxin A with citrinin and their metabolites (ochratoxin B, ochratoxin C, and dihydrocitrinone) on 2D/3D cell cultures, and zebrafish embryo modelsFood Chem. Toxicol.158112674(2021).
[5].Remiro, R., Ibáñez-Vea, M., González-Peñas, E., et al.Validation of a liquid chromatography method for the simultaneous quantification of ochratoxin A and its analogues in red winesJ. Chromatogr. A1217(52)8249-8256(2010).
| Cas No. | N/A | SDF | Download SDF |
| 别名 | Ochratoxin A-13C20 ethyl ester,OTC-13C20,OTA-13C20 ethyl ester | ||
| 分子式 | C2[13C]20H22ClNO6 | 分子量 | 451.7 |
| 溶解度 | Methanol: soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2139 mL | 11.0693 mL | 22.1386 mL |
| 5 mM | 0.4428 mL | 2.2139 mL | 4.4277 mL |
| 10 mM | 0.2214 mL | 1.1069 mL | 2.2139 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet