Octahydrocurcumin (Hexahydrobisdemethoxycurcumin)

Octahydrocurcumin is an active metabolite of curcumin that has diverse biological activities.^1,2,3,4 It scavenges DPPH radicals in a cell-free assay (IC₅₀ = 12.3 ?M).¹ Octahydrocurcumin (6.25 ?M) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels, production of nitric oxide (NO), and nuclear translocation of NF-?B in RAW 264.7 cells.² It is active against the bacteria B. subtilis, K. pneumoniae, E. coli, E. aerogenes, P. aeruginosa, and S. aureus, as well as C. albicans and the plant pathogenic fungus A. niger, in disc assays.³ Octahydrocurcumin (5, 10, and 20 mg/kg) increases survival, reduces tumor weight, and induces tumor cell apoptosis in an H22 murine hepatocellular carcinoma model.⁴

1.Deters, M., Knochenwefel, H., Lindhorst, D., et al.Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activitiesPharm. Res.25(8)1822-1827(2008) 2.Zhao, F., Gong, Y., Hu, Y., et al.Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: translocation of nuclear factor-κB as potential targetMol. Med. Rep.11(4)3087-3093(2015) 3.Singh, R.P., and Jain, D.A.Antimicrobial activity of hydrogenated derivatives of curcuminPharm. Res.5(7)3650-3653(2012) 4.Zhang, Z., Luo, D., Xie, J., et al.Octahydrocurcumin, a final hydrogenated metabolite of curcumin, possesses superior anti-tumor activity through induction of cellular apoptosisFood Funct.9(4)2005-2014(2018)