Octocrylene
(Synonyms: 奥克立林) 目录号 : GC30116
A UV filter
Cas No.:6197-30-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Octocrylene is a UV filter.1,2 It stabilizes the full-spectrum UVA blocker avobenzone to UV radiation.1 Octocrylene inhibits 17β-estradiol- or dihydrotestosterone-induced transactivation of estrogen receptor α (ERα) or the androgen receptor in S. cerevisiae expressing the human receptors (IC50s = 2.17 and 0.627 mM, respectively).2 Topical application of octocrylene (15 or 30% w/v) increases thymidine incorporation in a mouse local lymph node assay (LLNA), indicating allergenic activity.3 Octocrylene has been found in influent and effluent wastewater.4 Formulations containing octocrylene have been used in sunscreen products.
1.Beasley, D.G., and Meyer, T.A.Characterization of the UVA protection provided by avobenzone, zinc oxide, and titanium dioxide in broad-spectrum sunscreen productsAm. J. Clin. Dermatol.11(6)413-421(2010) 2.Kunz, P.Y., and Fent, K.Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fishAquat. Toxicol.79(4)305-324(2006) 3.Karlsson, I., Broecke, K.V., M?rtensson, J., et al.Clinical and experimental studies of octocrylene's allergenic potencyContact Dermatitis64(6)343-352(2011) 4.Balmer, M., Buser, H.-R., Müller, M.D., et al.Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss lakesEnviron. Sci. Technol.39(4)953-962(2005)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7664 mL | 13.832 mL | 27.664 mL |
| 5 mM | 0.5533 mL | 2.7664 mL | 5.5328 mL |
| 10 mM | 0.2766 mL | 1.3832 mL | 2.7664 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。