ω-Conotoxin GVIA (trifluoroacetate salt)
目录号 : GC45241
ω-Conotoxin GVIA is a peptide originally isolated from the marine mollusk C.
Sample solution is provided at 25 µL, 10mM.
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ω-Conotoxin GVIA is a peptide originally isolated from the marine mollusk C. geographus that acts as an N-type calcium channel blocker. It binds to human neocortical, rat hippocampal, and chick brain synaptic plasma membranes (IC50s = 4.6, 60, and 150 pM, respectively, in radioligand binding assays). ω-Conotoxin GVIA inhibits norepinephrine and acetylcholine release from human neocortical slices (IC50s = 14 and 3 nM, respectively) and calcium influx into chick synaptosomes by 92% when used at a concentration of 0.1 μM. It blocks electrically-evoked twitch responses of rat vas deferens and guinea pig ileum (IC50s = 9.8 and 55 nM, respectively) but does not affect the postjunctional contractile responses induced by norepinephrine on vas deferens or by carbamoylcholine on ileum. ω-Conotoxin GVIA does not affect potassium-induced contraction of rat aorta at concentrations up to 1 μM.
| Cas No. | SDF | ||
| 分子式 | C120H182N38O43S6•XCF3COOH | 分子量 | 3037.4 |
| 溶解度 | Water: 1 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.3292 mL | 1.6461 mL | 3.2923 mL |
| 5 mM | 0.0658 mL | 0.3292 mL | 0.6585 mL |
| 10 mM | 0.0329 mL | 0.1646 mL | 0.3292 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet