Ornidazole-d5
(Synonyms: Ro 7-0207-d5) 目录号 : GC48908An internal standard for the quantification of ornidazole
Cas No.:2747915-64-4
Sample solution is provided at 25 µL, 10mM.
Ornidazole-d5 is intended for use as an internal standard for the quantification of ornidazole by GC- or LC-MS. Ornidazole is an orally bioavailable 5-nitroimidazole derivative with antibacterial and antiprotozoal activities.1,2 Ornidazole inhibits the growth of clinical isolates of B. fragilis (MICs = 0.5-5 μM) and various anaerobic bacteria when used at concentrations ranging from less than 0.1 to 3.2 μg/ml.2,3 It also inhibits the growth of Giardia isolates (IC50s = 0.01-0.47 μg/ml).4 Oral administration of ornidazole reduces T. vaginalis and T. foetus infection in mice and E. histolytica infection in rats with curative dose (CD50) values of 37, 3, and 10 mg/kg, respectively.1 Ornidazole (400 mg/kg per day) induces infertility in male rats within 7 days and inhibits spermatozoa binding to rat oocyte zona pellucida.5,6
1.Hoffer, M., and Grunberg, E.Synthesis and antiprotozoal activity of 1-(3-chloro-2-hydroxypropyl)-substituted nitroimidazolesJ. Med. Chem.17(9)1019-1020(1974) 2.Jokipii, L., and Jokipii, A.M.Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis groupAntimicrob. Agents Chemother.28(4)561-564(1985) 3.WÜst, J.Susceptibility of anaerobic bacteria to metronidazole, ornidazole, and tinidazole and routine susceptibility testing by standardized methodsAntimicrob. Agents Chemother.11(4)631-637(1977) 4.Majewska, A.C., Kasprzak, W., De Jonckheere, J.F., et al.Heterogeneity in the sensitivity of stocks and clones of Giardia to metronidazole and ornidazoleTrans. R. Soc. Trop. Med. Hyg.85(1)67-69(1991) 5.OberlÄnder, G., Yeung, C.H., and Cooper, T.G.Induction of reversible infertility in male rats by oral ornidazole and its effects on sperm motility and epididymal secretionsJ. Reprod. Fertil.100(2)551-559(1994) 6.Bone, W., Jones, N.G., Kamp, G., et al.Effect of ornidazole on fertility of male rats: Inhibition of a glycolysis-related motility pattern and zona binding required for fertilization in vitroJ. Reprod. Fertil.118(1)127-135(2000)
Cas No. | 2747915-64-4 | SDF | |
别名 | Ro 7-0207-d5 | ||
Canonical SMILES | OC(C([2H])([2H])Cl)([2H])C([2H])([2H])N1C(C)=NC=C1[N+]([O-])=O | ||
分子式 | C7H5D5ClN3O3 | 分子量 | 224.7 |
溶解度 | DMSO: soluble,Methanol: soluble | 储存条件 | -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
||
Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 4.4504 mL | 22.2519 mL | 44.5038 mL |
5 mM | 0.8901 mL | 4.4504 mL | 8.9008 mL |
10 mM | 0.445 mL | 2.2252 mL | 4.4504 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet