Oxamyl-d6

Oxamyl-d₆ is intended for use as an internal standard for the quantification of oxamyl by GC- or LC-MS. Oxamyl is a carbamate pesticide and an inhibitor of acetylcholinesterase (AChE; IC₅₀ = 1.67 μM for the C. gigas enzyme).¹ It is nematocidal, decreasing the number of P. penetrans and M. hapla per gram of alfalfa (M. sativa) root when applied to seeds at a concentration of 50 mg/ml.² Oxamyl (50 and 100 μg/ml) is also toxic to citrus nematode (T. semipenetrans) larvae.³ In vivo, oxamyl (2.1 and 3.5 mg/kg) inhibits plasma and brain AChE, as well as liver glucose-6-phosphatase and mitochondrial complex II, also known as succinate dedrogenase, and reduces body weight gain in rats.⁴ Formulations containing oxamyl have been used to control nematode infestation of field crops.