Oxaprozin-d5
(Synonyms: Oxaprozinum-d5; Wy21743-d5) 目录号 : GC49054
An internal standard for the quantification of oxaprozin
Cas No.:2933758-40-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Oxaprozin-d5 is intended for use as an internal standard for the quantification of oxaprozin by GC- or LC-MS. Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 2.2 and 36 μM for human COX-1 and COX-2, respectively).1 It decreases acetic acid-induced writhing times and carrageenan-induced paw edema in mice when administered at doses of 100 and 70 mg/kg, respectively.2 Formulations containing oxaprozin have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.
1.Kawai, S., Nishida, S., Kato, M., et al.Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cellsEur. J. Pharmacol.347(1)87-94(1998) 2.Zhou, X.P., Zhang, M.X., Sun, W., et al.Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drugBiol. Pharm. Bull.32(12)1986-1990(2009)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3512 mL | 16.756 mL | 33.5121 mL |
| 5 mM | 0.6702 mL | 3.3512 mL | 6.7024 mL |
| 10 mM | 0.3351 mL | 1.6756 mL | 3.3512 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。