p-Methylphenyl potassium sulfate

p-Cresol sulfate is a sulfate conjugate of the uremic toxin p-cresol, which is formed by bacterial fermentation of proteins in the large intestine.^1,2 p-Cresol sulfate increases migration and proliferation of isolated rat aortic vascular smooth muscle cells (VSMCs) when used at a concentration of 500 ?M.³ It also increases the area of aortic atherosclerotic plaques in nephrectomized ApoE^-/- mice fed a high-fat diet when administered at a dose of 100 mg/kg per day via the drinking water. Serum levels of total and free p-cresol sulfate are increased in patients with advanced stage chronic kidney disease and positively associated with vascular calcification.⁴

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