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p53 tumor suppressor fragment Sale

(Synonyms: H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH ) 目录号 : GP10036

Regulates cell cycle

p53 tumor suppressor fragment Chemical Structure

规格 价格 库存 购买数量
1mg
¥368.00
现货
5mg
¥1,029.00
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10mg
¥1,712.00
现货
25mg
¥2,699.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

p53 tumor suppressor fragment (232-240),(C41H67N11O14S4), a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene1. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation2. p53 has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. In its anti-cancer role, p53 works through several mechanisms:It can activate DNA repair proteins when DNA has sustained damage. It can induce growth arrest by holding the cell cycle at the G1/S regulation point on DNA damage recognition.It can initiate apoptosis, the programmed cell death, if DNA damage proves to be irreparable3.

References:
1. Cho, Y.; Gorina, S.; Jeffrey, P. D.; Pavletich, N. P. (1994). "Crystalstructure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations". Science 265 (5170): 346-355.
2. Read, A. P.; Strachan, T.. Human molecular genetics 2. New York: Wiley; 1999. ISBN 0-471-33061-2. Chapter 18: Cancer Genetics.
3. May P, May E. Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene. 1999;18(53):7621-36.

Chemical Properties

Cas No. SDF
别名 H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH
Canonical SMILES NC(CCCCN)C(NC(CC1=CC=C(O)C=C1)C(NC(CCSC)C(NC(CS)C(NC(CC(N)=O)C(NC(CO)C(NC(CO)C(NC(CS)C(NC(CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
分子式 C41H67N11O14S4 分子量 1066.3
溶解度 ≥ 53.3mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 0.9378 mL 4.6891 mL 9.3782 mL
5 mM 0.1876 mL 0.9378 mL 1.8756 mL
10 mM 0.0938 mL 0.4689 mL 0.9378 mL
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