Paclitaxel-d5

Paclitaxel-d₅ contains five deuterium atoms. It is intended for use as an internal standard for the quantification of paclitaxel using GC- or LC-MS. Paclitaxel is cytotoxic against a variety of cancer cell lines with IC₅₀ values ranging from 2.5-7.5 nM.¹ It disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC₅₀s = 6.7-18.5 nM) at both prophase and G₁.² It also initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.³

1.Liebmann, J.E., Cook, J.A., Lipschultz, C., et al.Cytotoxic studies of paclitaxel (Taxol) in human tumour cell linesBr. J. Cancer68(6)1104-1109(1993) 2.Woods, C.M., Zhu, J., McQueney, P.A., et al.Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathwayMol. Med.1(5)506-526(1995) 3.Wang, T.h., Wang, H.S., and Soong, Y.K.Paclitaxel-induced cell death: Where the cell cycle and apoptosis come togetherCancer88(11)2619-2628(2000)