Palmitoyl-Coenzyme A (sodium salt)
(Synonyms: Hexadecanoyl-CoA,Palmitoyl-CoA) 目录号 : GC91833Palmitoyl-Coenzyme A (palmitoyl-CoA) is a derivative of CoA that contains the saturated fatty acid palmitic acid .
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Palmitoyl-Coenzyme A (palmitoyl-CoA) is a derivative of CoA that contains the saturated fatty acid palmitic acid . It is a substrate for palmitoyltransferases during palmitoylation, a process that adds a palmitoyl group to proteins to anchor them to the membrane or target them to lipid rafts.[1] It is also a substrate in the de novo synthesis of sphingolipids.2,3 Palmitoyl-CoA binds to acyl-CoA-binding protein (ACBP; Kd = 0.45 pM) and undergoes β-oxidation in mitochondria.[4]
References:
[1].Guan, X., and Fierke, C.A.Understanding protein palmitoylation: Biological significance and enzymologySci. China Chem.54(12)1888-1897(2011).
[2].Weiss, B., and Stoffel, W.Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesisEur. J. Biochem.249239-247(1997).
[3].Lai, M.K.P., Chew, W.S., Torta, F., et al.Biological effects of naturally occurring sphingolipids, uncommon variants, and their analogsNeuromolecular Med.18(3)396-414(2016).
[4].Rasmussen, J.T., Faergeman, N.J., Kristiansen, K., et al.Acyl-CoA-binding protein (ACBP) can mediate intermembrane acyl-CoA transport and donate acyl-CoA for β-oxidation and glycerolipid synthesisBiochem. J.299(Pt 1)165-170(1994).
| Cas No. | N/A | SDF | Download SDF |
| 别名 | Hexadecanoyl-CoA,Palmitoyl-CoA | ||
| 分子式 | C37H66N7O17P3S•XNa | 分子量 | 1005.9 |
| 溶解度 | Methanol: Soluble,Water: Soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.9941 mL | 4.9707 mL | 9.9413 mL |
| 5 mM | 0.1988 mL | 0.9941 mL | 1.9883 mL |
| 10 mM | 0.0994 mL | 0.4971 mL | 0.9941 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。