PAMAM Dendrimer G4.0 Amidoethanol (water solution)

PAMAM dendrimer G4.0 amidoethanol (PAMAM G4.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini that has been used as a drug delivery system in vivo.¹ It is approximately 45 Å in diameter and has 64 surface groups.² Conjugates of PAMAM G4.0 amidoethanol and the synthetic glucocorticoid methylprednisolone decrease ovalbumin-induced increases in the number of eosinophils in bronchoalveolar lavage fluid (BALF) and lung tissue to a greater extent than methylprednisolone alone in a mouse model of lung inflammation.¹ PAMAM G4.0 amidoethanol is toxic to the cyanobacteria Anabaena and green alga C. reinhardtii (EC₉₀s = 5.13 and 1.02 mg/L, respectively) and induces the formation of reactive oxygen species (ROS) in both.³ Unlike PAMAM G3.0, -G4.0, -G5.0, and -G6.0-NH₂, PAMAM G4.0 amidoethanol is unable to transfect cells.⁴

References:
[1]. Inapagolla, R., Guru, B.R., Kurtoglu, Y.E., et al.In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammationInt. J. Pharm.399(1-2)140-147(2012).
[2]. Bai, L., Wan, H., and Street, S.C.Preparation of ultrafine FePt nanoparticles by chemical reduction in PAMAM-OH templateColloids Surf. A Physicochem.349(1-3)23-28(2009).
[3]. Gonzalo, S., Rodea-Palomares, I., LeganÉs, F., et al.First evidences of PAMAM dendrimer internalization in microorganisms of environmental relevance: A linkage with toxicity and oxidative stressNanotoxicology9(6)706-718(2015).
[4]. Shakhbazau, A., Isayenka, I., Kartel, N., et al.Transfection efficiencies of PAMAM dendrimers correlate inversely with their hydrophobicityInt. J. Pharm.383(1-2)228-235(2010).