PAMAM Dendrimer G5.0 Amidoethanol (water solution)
(Synonyms: PAMAM 5.0 Amidoethanol; Polyamidoamine Dendrimer G5.0 Amidoethanol) 目录号 : GC92137PAMAM dendrimer G5.0 amidoethanol (PAMAM G3.0-amidoethanol ) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini.
Sample solution is provided at 25 µL, 10mM.
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PAMAM dendrimer G5.0 amidoethanol (PAMAM G3.0-amidoethanol ) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini.1 It is approximately 51 Å in diameter in PBS and has 128 surface groups. PAMAM G3.0-amidoethanol dendrimers encapsulating gold nanoparticles induce oxidation of carbon monoxide in a cell-free assay.2 It binds to bilirubin (Kd = 8.5 µM).3 PAMAM G5.0 aminoethanol is active against S. aureus.4 It inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells when used at a concentration of 10 µM.5 PAMAM G3.0-amidoethanol has been used in the formation and isolation of platinum nanoclusters for in vitro breast cancer subtyping.6
References:
[1]. Dobrovolskaia, M.A., Patri, A.K., Simak, J., et al.Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitroMol. Pharm.9(3)382-393(2012).
[2]. Kracke, P., Haas, T., Saltsburg, H., et al.CO oxidation on unsupported dendrimer-encapsulated gold nanoparticlesJ. Phys. Chem. C114(39)16401-16407(2010).
[3]. Shcharbin, D., and Bryszewska, M.Complex formation between endogenous toxin bilirubin and polyamidoamine dendrimers: A spectroscopic studyBiochim. Biophys. Acta1760(7)1021-1026(2006).
[4]. Altaher, Y., and Kandeel, M.Structure-activity relationship of anionic and cationic polyamidoamine (PAMAM) dendrimers against Staphylococcus aureusJ. Nanomater.4013016(2022).
[5]. Kandeel, M., Al-Taher, A., Park, B.K., et al.A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirusJ. Med. Virol.92(9)1665-1670(2020).
[6]. Tanaka, S.-i., Wadati, H.S., K., Yasuda, H., et al.Red-fluorescent Pt nanoclusters for detecting and imaging HER2 in breast cancer cellsACS Omega5(37)23718-23723(2020).
| Cas No. | SDF | ||
| 别名 | PAMAM 5.0 Amidoethanol; Polyamidoamine Dendrimer G5.0 Amidoethanol | ||
| Canonical SMILES | CCCCC[C@@H](O)/C=C/[C@H]([C@H]1CCCCCCC(O)=O)C=CC1=O | ||
| 分子式 | [NH2(CH2)2NH2]:(G=5);dendri PAMAM(NHCH2CH2OH)128 | 分子量 | 28950.9 |
| 溶解度 | 储存条件 | -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.0345 mL | 0.1727 mL | 0.3454 mL |
| 5 mM | 0.0069 mL | 0.0345 mL | 0.0691 mL |
| 10 mM | 0.0035 mL | 0.0173 mL | 0.0345 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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