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Pancuronium dibromide Sale

(Synonyms: 泮库溴铵) 目录号 : GC11773

Pancuronium dibromide 是一种双季铵盐类固醇,是一种神经肌肉松弛剂。

Pancuronium dibromide Chemical Structure

Cas No.:15500-66-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥410.00
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25mg
¥483.00
现货
50mg
¥935.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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实验参考方法

Animal experiment [1]:

Animal models

Rats

Dosage form

2 mg/kg, i.v.

Application

Two effects of pancuronium bromide on heart rate in vivo: A short-lasting injection effect, which may be due to an indirect sympathomimetic action, and a longer-lasting potentiation of cardiac sympathetic responses which is at least partly due to blockade of neuronal noradrenaline uptake.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1] Docherty JR, McGrath JC. Potentiation of cardiac sympathetic nerve responses in vivo by pancuronium bromide. Br J Pharmacol. 1977 Nov;61(3):472P-473P.

产品描述

Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.Target: nAChRPancuronium Dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium Dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuronium dibromide is a non-depolarizing agent. Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is (unlike suxamethonium) a non-depolarizing agent, which means that it causes no spontaneous depolarizations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration [1-3].

References:
[1]. Fryer, A.D. and J. Maclagan, Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol, 1987. 335(4): p. 367-71.
[2]. Maestrone, E., et al., Extracellular pancuronium affects sodium current in chick embryo sensory neurones. Br J Pharmacol, 1994. 111(1): p. 283-7.
[3]. Lowenick, C.V., et al., Open channel and competitive block of nicotinic receptors by pancuronium and atracurium. Eur J Pharmacol, 2001. 413(1): p. 31-5.

Chemical Properties

Cas No. 15500-66-0 SDF
别名 泮库溴铵
化学名 [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;dibromide
Canonical SMILES CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
分子式 C35H60N2O4.2Br 分子量 732.67
溶解度 ≥ 36.6335mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.3649 mL 6.8244 mL 13.6487 mL
5 mM 0.273 mL 1.3649 mL 2.7297 mL
10 mM 0.1365 mL 0.6824 mL 1.3649 mL
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