Home>>Peptides>>PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA))

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) Sale

(Synonyms: PAR-4-AP TFA; AY-NH2 TFA) 目录号 : GC33599

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) (PAR-4-AP TFA; AY-NH2 TFA) 是一种蛋白酶激活的受体 4 (PAR-4) 激动剂,没有作用在 PAR-1 或 PAR-2 上,其作用被 PAR-4 拮抗剂阻断。

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) Chemical Structure

Cas No.:1228078-65-6

规格 价格 库存 购买数量
1 mg
¥540.00
现货
5 mg
¥1,620.00
现货
10 mg
¥2,700.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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实验参考方法

Animal experiment:

Mice[1]SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].

References:

[1]. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.

产品描述

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1].

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].

[1]. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.

Chemical Properties

Cas No. 1228078-65-6 SDF
别名 PAR-4-AP TFA; AY-NH2 TFA
Canonical SMILES Ala-Tyr-Pro-Gly-Lys-Phe-NH2
分子式 C36H49F3N8O9 分子量 794.82
溶解度 DMSO : ≥ 250 mg/mL (314.54 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.2581 mL 6.2907 mL 12.5815 mL
5 mM 0.2516 mL 1.2581 mL 2.5163 mL
10 mM 0.1258 mL 0.6291 mL 1.2581 mL
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