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Paraherquamide E Sale

(Synonyms: 对郝喹酰胺E) 目录号 : GC44564

A fungal metabolite

Paraherquamide E Chemical Structure

Cas No.:125600-53-5

规格 价格 库存 购买数量
500μg
¥5,567.00
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2.5mg
¥16,702.00
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产品描述

Paraherquamide E is a fungal metabolite originally isolated from P. charlesii with anthelmintic and insecticidal activities. It is lethal to C. elegans (LD50 = 6 μg/ml). Paraherquamide E is also lethal to O. fasciatus (LD50 = 0.089 μg/nymph). Oral administration of paraherquamide E (0.5-4 mg/kg) reduces T. colubriformis fecal egg count in gerbils.

Chemical Properties

Cas No. 125600-53-5 SDF
别名 对郝喹酰胺E
Canonical SMILES CC(C=CO1)(C)OC2=C1C(NC([C@]34C[C@](CN(CC[C@@H]5C)[C@]5(C6=O)C7)(N6C)[C@]7([H])C3(C)C)=O)=C4C=C2
分子式 C28H35N3O4 分子量 477.6
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mM 2.0938 mL 10.469 mL 20.938 mL
5 mM 0.4188 mL 2.0938 mL 4.1876 mL
10 mM 0.2094 mL 1.0469 mL 2.0938 mL
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Research Update

Paraherquamide E

Acta Crystallogr Sect E Struct Rep Online 2010 Aug 11;66(Pt 9):o2227.PMID:21588597DOI:10.1107/S1600536810030795.

In the title compound, C(28)H(35)N(3)O(4), also known as 14-de-oxy-paraherquamide A,the two pyrrolidine rings adopt envelope conformations. The piperazine ring of the diaza-bicyclo-[2.2.2]octan-3-one unit adopts a boat conformation whereas the two piperidine rings are in distorted boat conformations. Intra-molecular C-H⋯O hydrogen bonds are observed. In the crystal, the mol-ecules are linked into chains along the b axis by inter-molecular N-H⋯O hydrogen bonds.

Studies on Paraherquamide Biosynthesis: Synthesis of Deuterium-Labeled 7-Hydroxy-Pre-Paraherquamide, a Putative Precursor of Paraherquamides A, E & F

Tetrahedron 2009 Apr 18;65(16):3246-3260.PMID:20161298DOI:10.1016/j.tet.2008.08.102.

The stereocontrolled, asymmetric synthesis of triply deuterium-labeled 7-hydroxy-pre-paraherquamide (27) was accomplished, employing a diastereoselective intramolecular S(N)2' cyclization strategy. The deuterium-labeled substrate was interrogated in a precursor incorporation experiment in the paraherquamide-producing organism Penicillium fellutanum. The isolated sample of paraherquamide A revealed incorporation of one of the two geminal deuterons of the CD(2)-group at C-12 exclusively. The lack of signals for the second deuteron of the CD(2)-group at C-12 and for the CH(2)D-group (C-22/C-23) suggests that this substrate suffered an unexpectedly selective catabolic degradation and metabolic re-incorporation of deuterium thus casting doubt on the proposed biosynthetic intermediacy of 27. Consideration of alternative biosynthetic pathways, including oxidation of the indole C-6 position prior to hydroxylation at C-7 or oxidative spiro-contraction of pre-paraherquamide prior to construction of the dioxepin is discussed. The synthesis of 27 also provides for a concise, asymmetric stereocontrolled synthesis of an advanced intermediate that will be potentially useful in the synthesis of Paraherquamide E & F.

Insecticidal activity of Paraherquamides, including paraherquamide H and paraherquamide I, two new alkaloids isolated from Penicillium cluniae

J Agric Food Chem 2006 Apr 19;54(8):2921-5.PMID:16608209DOI:10.1021/jf0530998.

Paraherquamide H (1) and paraherquamide I (2), two new compounds of the paraherquamide (PHQ) family, together with the already known paraherquamide A (3), paraherquamide B (4), Paraherquamide E (5), VM55596 (N-oxide paraherquamide) (6), paraherquamide VM55597 (7), and five known diketopiperazines (8-12) have been isolated from the culture broth of Penicillium cluniae Quintanilla. The structure of 1 and 2, on the basis of NMR and MS analysis, was established. It is worth noticing that, in both cases, an unusual oxidative substitution in C-16 was found, which had only previously been detected in PHQ 7. Isolated compounds were tested for insecticidal activity against the hemipteran Oncopeltus fasciatus Dallas. Mortality data have allowed preliminary structure activity relationships to be proposed. The most potent product was 5 with a LD(50) of 0.089 microg/nymph.

Identification of Therapeutic Targets in an Emerging Gastrointestinal Pathogen Campylobacter ureolyticus and Possible Intervention through Natural Products

Antibiotics (Basel) 2022 May 18;11(5):680.PMID:35625323DOI:10.3390/antibiotics11050680.

Campylobacter ureolyticus is a Gram-negative, anaerobic, non-spore-forming bacteria that causes gastrointestinal infections. Being the most prevalent cause of bacterial enteritis globally, infection by this bacterium is linked with significant morbidity and mortality in children and immunocompromised patients. No information on pan-therapeutic drug targets for this species is available yet. In the current study, a pan-genome analysis was performed on 13 strains of C. ureolyticus to prioritize potent drug targets from the identified core genome. In total, 26 druggable proteins were identified using subtractive genomics. To the best of the authors' knowledge, this is the first report on the mining of drug targets in C. ureolyticus. UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) was selected as a promiscuous pharmacological target for virtual screening of two bacterial-derived natural product libraries, i.e., postbiotics (n = 78) and streptomycin (n = 737) compounds. LpxC inhibitors from the ZINC database (n = 142 compounds) were also studied with reference to LpxC of C. ureolyticus. The top three docked compounds from each library (including ZINC26844580, ZINC13474902, ZINC13474878, Notoginsenoside St-4, Asiaticoside F, Paraherquamide E, Phytoene, Lycopene, and Sparsomycin) were selected based on their binding energies and validated using molecular dynamics simulations. To help identify potential risks associated with the selected compounds, ADMET profiling was also performed and most of the compounds were considered safe. Our findings may serve as baseline information for laboratory studies leading to the discovery of drugs for use against C. ureolyticus infections.

Itaconic acid derivatives and diketopiperazine from the marine-derived fungus Aspergillus aculeatus CRI322-03

Phytochemistry 2011 Jun;72(8):816-20.PMID:21397285DOI:10.1016/j.phytochem.2011.02.013.

Three metabolites, pre-aurantiamine (1), (-)-9-hydroxyhexylitaconic acid (4) and (-)-9-hydroxyhexylitaconic acid-4-methyl ester (5), together with two known compounds, Paraherquamide E (6) and secalonic acid D (7), were isolated from the marine-derived fungus, Aspergillus aculeatus.