Pargyline (hydrochloride)
(Synonyms: 优降宁盐酸盐；盐酸帕吉林；巴吉林盐酸盐) 目录号 : GC16824
An irreversible MAO inhibitor
Cas No.:306-07-0
Sample solution is provided at 25 µL, 10mM.
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IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).
IC50: 8.2 nM: blocks MAO type B (MAO-B).
Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells. There are two isoforms of MAO, MAO-A and MAO-B. MAO-A preferentially deaminates melatonin, serotonin, norepinephrine and epinephrine. MAO-B catalyzes the oxidative deamination and inactivation of certain catecholamines within the presynaptic nerve terminals.
In vitro: Pargyline reduced the proliferation of human prostate carcinoma (LNCaP-LN3) cells in a time- and dose-dependent fashion. In addition, compared to the control, pargyline remarkably triggered cell cycle arrest at the G1 phase. Pargyline elicited an increase in the cell death rate via promoting apoptosis, suggesting that pargyline was a powerful candidate drug for the treatment of human prostate cancer [1].
In vivo: Male rats were injected intraperitoneally pargyline at a dose of 75 mg/kg for 80 min. Pargyline significantly increased the concentration of extracellular dopamine in the striatum and simultaneously, significantly reduced the concentration of extracellular MAO-derived metabolite 3,4-dihydroxyphenylacetic acid to undetectable levels [2].
References:
[1]. Chai, Y. Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncology Reports. 2013.
[2]. Desvignes, C., Bert, L., Vinet, L., Denoroy, L., Renaud, B., & Lambás-Seas, L. Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic acid. Neuroscience Letters. 1999; 261(3):175-178.
| Cas No. | 306-07-0 | SDF | |
| 别名 | 优降宁盐酸盐；盐酸帕吉林；巴吉林盐酸盐 | ||
| 化学名 | N-methyl-N-2-propynyl-benzenemethanamine, monohydrochloride | ||
| Canonical SMILES | CN(CC#C)CC1=CC=CC=C1.Cl | ||
| 分子式 | C11H13N • HCl | 分子量 | 195.7 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 5mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.1099 mL | 25.5493 mL | 51.0986 mL |
| 5 mM | 1.022 mL | 5.1099 mL | 10.2197 mL |
| 10 mM | 0.511 mL | 2.5549 mL | 5.1099 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet