Paroxypropione (4'-Hydroxypropiophenone)
(Synonyms: 4-羟基苯丙酮,4'-Hydroxypropiophenone) 目录号 : GC32409
4'-Hydroxypropiophenone (Paroxypropione, p-hydroxypropiophenone) is a member of acetophenones.
Cas No.:70-70-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
4'-Hydroxypropiophenone (Paroxypropione, p-hydroxypropiophenone) is a member of acetophenones.
| Cas No. | 70-70-2 | SDF | |
| 别名 | 4-羟基苯丙酮,4'-Hydroxypropiophenone | ||
| Canonical SMILES | CCC(C1=CC=C(O)C=C1)=O | ||
| 分子式 | C9H10O2 | 分子量 | 150.17 |
| 溶解度 | DMSO : 100 mg/mL (665.91 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.6591 mL | 33.2956 mL | 66.5912 mL |
| 5 mM | 1.3318 mL | 6.6591 mL | 13.3182 mL |
| 10 mM | 0.6659 mL | 3.3296 mL | 6.6591 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Mass transport properties of co(polyether)polyurethane membranes II: permeability and sorption characteristics
J Pharm Sci 1981 Dec;70(12):1313-8.PMID:7320843DOI:10.1002/jps.2600701206.
A series of co(polyether)polyurethane polymers containing polyethylene glycol 600, 1000, or 1540 was synthesized, purified by reprecipitation, and cast into clear, tough, flexible membranes using the solution method. Hydration and membrane swelling increased with increasing polyethylene glycol molecular weight. Paroxypropione, 5-nitrosalicylic acid, sulfaguanidine, and phenylbutazone were used as penetrants of a 1 mM donor concentration. Transport rates through the 1540 and 1000 copolymer membranes were in decreasing order: Paroxypropione greater than 5-nitrosalicylic acid greater than sulfaguanidine greater than phenylbutazone; however, through the 600 copolymer membrane the rates were Paroxypropione greater than 5-nitrosalicylic acid approximately sulfaguanidine. Phenylbutazone did not penetrate during the experiment. Good agreement was obtained between apparent diffusion coefficients calculated by both the time lag and nonsteady-state methods. Boundary layer effects were examined by variations in stirring speeds. Evidence that diffusion may occur primarily through the aqueous region of the hydrated membranes is presented.