PDIC-NC
目录号 : GC91595PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.
Cas No.:2633013-75-7
Sample solution is provided at 25 µL, 10mM.
PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.[1],[2] It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM.[1] PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml, respectively).[2] It increases the levels of reactive oxygen species (ROS) and decreases the oxygen consumption rate (OCR) in A549 and NCI H446 cells when used at concentrations of 1 and 2 µg/ml, respectively. PDIC-NC selectively accumulates in the lungs over the heart, liver, spleen, and kidneys in mice. Intravenous administration of PDIC-NC (2 mg/kg) reduces tumor volume and the number of metastases in A549 mouse xenograft models.
References:
[1].Zhao, X., Zheng, R., Zhang, B., et al.Sulfonated perylene as three-in-one STING agonist for cancer chemo-immunotherapyAngew. Chem. Int. Ed. Engl.63(11)e202318799(2024).
[2].Liu, Z., Wang, X., Chen, Q., et al.Regulating twisted skeleton to construct organ-specific perylene for intensive cancer chemotherapyAngew Chem. Int. Ed. Engl.60(29)16215-16223(2021).
Cas No. | 2633013-75-7 | SDF | Download SDF |
分子式 | C32H24Cl4N4O4•2HCl | 分子量 | 743.3 |
溶解度 | Acetonitrile: Slightly soluble: 0.1-1 mg/ml,Methanol: Slightly soluble: 0.1-1 mg/ml | 储存条件 | -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 1.3454 mL | 6.7268 mL | 13.4535 mL |
5 mM | 0.2691 mL | 1.3454 mL | 2.6907 mL |
10 mM | 0.1345 mL | 0.6727 mL | 1.3454 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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