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PDIC-NC

目录号 : GC91595

PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.

PDIC-NC Chemical Structure

Cas No.:2633013-75-7

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1 mg
¥364.00
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5 mg
¥1,372.00
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10 mg
¥2,184.00
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产品描述

PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.[1],[2] It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM.[1] PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml, respectively).[2] It increases the levels of reactive oxygen species (ROS) and decreases the oxygen consumption rate (OCR) in A549 and NCI H446 cells when used at concentrations of 1 and 2 µg/ml, respectively. PDIC-NC selectively accumulates in the lungs over the heart, liver, spleen, and kidneys in mice. Intravenous administration of PDIC-NC (2 mg/kg) reduces tumor volume and the number of metastases in A549 mouse xenograft models.

References:
[1].Zhao, X., Zheng, R., Zhang, B., et al.Sulfonated perylene as three-in-one STING agonist for cancer chemo-immunotherapyAngew. Chem. Int. Ed. Engl.63(11)e202318799(2024).
[2].Liu, Z., Wang, X., Chen, Q., et al.Regulating twisted skeleton to construct organ-specific perylene for intensive cancer chemotherapyAngew Chem. Int. Ed. Engl.60(29)16215-16223(2021).

Chemical Properties

Cas No. 2633013-75-7 SDF Download SDF
分子式 C32H24Cl4N4O4•2HCl 分子量 743.3
溶解度 Acetonitrile: Slightly soluble: 0.1-1 mg/ml,Methanol: Slightly soluble: 0.1-1 mg/ml 储存条件 -20°C
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1 mg 5 mg 10 mg
1 mM 1.3454 mL 6.7268 mL 13.4535 mL
5 mM 0.2691 mL 1.3454 mL 2.6907 mL
10 mM 0.1345 mL 0.6727 mL 1.3454 mL
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