PDIC-NS
目录号 : GC91820PDIC-NS is an activator of stimulator of interferon genes (STING).
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
PDIC-NS is an activator of stimulator of interferon genes (STING).[1] It increases the levels of reactive oxygen species (ROS) and induces apoptosis in LL/2 lung carcinoma cells when used at a concentration of 2.5 µM. PDIC-NS (2.5 µM) induces cell cycle arrest at the S phase, increases cytosolic levels of mitochondrial DNA (mtDNA), and increases levels of phosphorylated TANK-binding kinase 1 (Tbk1), interferon regulating factor 3 (Irf3), and STING in, as well as increases secretion of 2',3'-cGAMP and ATP from, LL/2 cells. It decreases tumor volume and weight and increases the percentage of intratumoral M1 macrophages and mature dendritic cells in an LL/2 mouse xenograft model when administered at a dose of 2 mg/kg twice per day. PDIC-NS (2.5 mg/kg twice per day) reduces lung weight and the number of lung metastases in wild-type and Sting1-/- mice in an LL/2 model of lung metastasis. It also increases serum levels of Ifn-β, Ifn-γ, Tnf-α, and chemokine (C-X-C motif) ligand 10 (Cxcl10), as well as increases the percentage of intratumoral CD4+, CD8+, and CD38+ T cells, in wild-type mice, and, to a lesser extent, in Sting1-/- mice, in the same model.
References:
[1].Zhao, X., Zheng, R., Zhang, B., et al.Sulfonated perylene as three-in-one STING agonist for cancer chemo-immunotherapyAngew. Chem. Int. Ed. Engl.63(11)e202318799(2024).
Cas No. | N/A | SDF | Download SDF |
分子式 | C32H26Cl4N4O4•2CH3SO3 | 分子量 | 862.6 |
溶解度 | DMSO: soluble,Water: slightly soluble | 储存条件 | -20°C |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
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1 mg | 5 mg | 10 mg | |
1 mM | 1.1593 mL | 5.7964 mL | 11.5929 mL |
5 mM | 0.2319 mL | 1.1593 mL | 2.3186 mL |
10 mM | 0.1159 mL | 0.5796 mL | 1.1593 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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% DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度: mg/ml;
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2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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