Home>>Signaling Pathways>> Immunology/Inflammation>>PDIC-NS

PDIC-NS

目录号 : GC91820

PDIC-NS is an activator of stimulator of interferon genes (STING).

PDIC-NS Chemical Structure

规格 价格 库存 购买数量
1 mg
¥350.00
现货
5 mg
¥1,316.00
现货
10 mg
¥2,450.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

PDIC-NS is an activator of stimulator of interferon genes (STING).[1] It increases the levels of reactive oxygen species (ROS) and induces apoptosis in LL/2 lung carcinoma cells when used at a concentration of 2.5 µM. PDIC-NS (2.5 µM) induces cell cycle arrest at the S phase, increases cytosolic levels of mitochondrial DNA (mtDNA), and increases levels of phosphorylated TANK-binding kinase 1 (Tbk1), interferon regulating factor 3 (Irf3), and STING in, as well as increases secretion of 2',3'-cGAMP and ATP from, LL/2 cells. It decreases tumor volume and weight and increases the percentage of intratumoral M1 macrophages and mature dendritic cells in an LL/2 mouse xenograft model when administered at a dose of 2 mg/kg twice per day. PDIC-NS (2.5 mg/kg twice per day) reduces lung weight and the number of lung metastases in wild-type and Sting1-/- mice in an LL/2 model of lung metastasis. It also increases serum levels of Ifn-β, Ifn-γ, Tnf-α, and chemokine (C-X-C motif) ligand 10 (Cxcl10), as well as increases the percentage of intratumoral CD4+, CD8+, and CD38+ T cells, in wild-type mice, and, to a lesser extent, in Sting1-/- mice, in the same model.

References:
[1].Zhao, X., Zheng, R., Zhang, B., et al.Sulfonated perylene as three-in-one STING agonist for cancer chemo-immunotherapyAngew. Chem. Int. Ed. Engl.63(11)e202318799(2024).

Chemical Properties

Cas No. N/A SDF Download SDF
分子式 C32H26Cl4N4O4•2CH3SO3 分子量 862.6
溶解度 DMSO: soluble,Water: slightly soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.1593 mL 5.7964 mL 11.5929 mL
5 mM 0.2319 mL 1.1593 mL 2.3186 mL
10 mM 0.1159 mL 0.5796 mL 1.1593 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置