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PDMP (hydrochloride)

(Synonyms: DL-erythro/threo-PDMP) 目录号 : GC44587

An inhibitor of sphingolipid biosynthesis

PDMP (hydrochloride) Chemical Structure

Cas No.:73257-80-4

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10mg
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25mg
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100mg
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Sample solution is provided at 25 µL, 10mM.

Description

PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase. PDMP has two adjacent chiral centers (C1 and C2) allowing for the formation of four possible isomers. PDMP contains all four of these stereoisomers. PDMP inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates, however, the ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer. The D-threo PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. PDMP enhances curcumin-induced inhibition of proliferation, JNK activation, and Akt inhibition, as well as induction of apoptosis in WM-115 melanoma cells in vitro.

化学性质

Cas No. 73257-80-4 SDF
别名 DL-erythro/threo-PDMP
Canonical SMILES CCCCCCCCCC(N([H])C(C(O)C1=CC=CC=C1)CN2CCOCC2)=O.Cl
分子式 C23H38N2O3•HCl 分子量 427
溶解度 DMF: 25 mg/ml,DMSO: 30 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS(pH 7.2)(1:5): .05 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 2.3419 mL 11.7096 mL 23.4192 mL
5 mM 0.4684 mL 2.3419 mL 4.6838 mL
10 mM 0.2342 mL 1.171 mL 2.3419 mL
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