Pentacosanoic Acid
(Synonyms: 二十五烷酸) 目录号 : GC44592
A saturated long-chain fatty acid
Cas No.:506-38-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Pentacosanoic acid is a 25-carbon, fully saturated long-chain fatty acid found in plant lipids.
| Cas No. | 506-38-7 | SDF | |
| 别名 | 二十五烷酸 | ||
| Canonical SMILES | CCCCCCCCCCCCCCCCCCCCCCCCC(O)=O | ||
| 分子式 | C25H50O2 | 分子量 | 382.7 |
| 溶解度 | Chloroform: 2.5 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.613 mL | 13.0651 mL | 26.1301 mL |
| 5 mM | 0.5226 mL | 2.613 mL | 5.226 mL |
| 10 mM | 0.2613 mL | 1.3065 mL | 2.613 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Pentadecanoic and Heptadecanoic Acids: Multifaceted Odd-Chain Fatty Acids
Adv Nutr 2016 Jul 15;7(4):730-4.PMID:27422507DOI:10.3945/an.115.011387.
The odd-chain fatty acids (OCFAs) pentadecanoic acid (15:0) and heptadecanoic acid (17:0), which account for only a small proportion of total saturated fatty acids in milk fat and ruminant meat, are accepted biomarkers of dairy fat intake. However, they can also be synthesized endogenously, for example, from gut-derived propionic acid (3:0). A number of studies have shown an inverse association between OCFA concentrations in human plasma phospholipids or RBCs and risk of type 2 diabetes and cardiovascular disease. We propose a possible involvement in metabolic regulation from the assumption that there is a link between 15:0 and 17:0 and the metabolism of other short-chain, medium-chain, and longer-chain OCFAs. The OCFAs 15:0 and 17:0 can be elongated to very-long-chain FAs (VLCFAs) such as tricosanoic acid (23:0) and Pentacosanoic Acid (25:0) in glycosphingolipids, particularly found in brain tissue, or can be derived from these VLCFAs. Their chains can be shortened, yielding propionyl-coenzyme A (CoA). Propionyl-CoA, by succinyl-CoA, can replenish the citric acid cycle (CAC) with anaplerotic intermediates and, thus, improve mitochondrial energy metabolism. Mitochondrial function is compromised in a number of disorders and may be impaired with increasing age. Optimizing anaplerotic intermediate availability for the CAC may help to cope with demands in times of increased metabolic stress and with aging. OCFAs may serve as substrates for synthesis of both odd-numbered VLCFAs and propionyl-CoA or store away excess propionic acid.
Antibacterial Flavonoids and Other Compounds from the Aerial Parts of Vernonia guineensis Benth. (Asteraceae)
Chem Biodivers 2020 Sep;17(9):e2000296.PMID:32658364DOI:10.1002/cbdv.202000296.
An extensive phytochemical study of the aerial parts of Vernonia guineensis Benth. (Asteraceae) led to the isolation of a new flavone, vernoguinoflavone and a naturally isolated glycerol ester, eicosanoic acid 2-hydroxy-1,3-propanediyl ester, together with eighteen known secondary metabolites including quercetin, luteolin, vernopicrin, vernomelitensin, β-amyrin, oleanolic acid, ursolic acid, lupeol, betulinic acid, β-carotene, a mixture of stigmasterol and β-sitosterol, β-sitosterol-3-O-β-D-glucoside, 2,3-dihydroxypropyl heptacosanoate, Pentacosanoic Acid, docosan-1-ol, tritriacontan-1-ol, and heptatriacontan-1-ol. Eleven compounds are reported herein for the first time from this species. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, particularly 1D and 2D NMR, and HR-ESI-MS and by comparison of their data with those reported in the literature. The crude extract, fractions and some isolated compounds were evaluated for their antibacterial activity against Gram-negative bacteria: Escherichia coli (ATCC 25922), Shigella flexineri (NR 518), Salmonella muenchen, Salmonella typhimurium and Salmonella typhi (ATCC 19430). All the tested compounds demonstrated inhibitory activities against the tested enteric bacteria with MIC values ranging from 3.12 to 100 μg/ml. Three flavonoids isolated from the most active fraction demonstrated the best bioactivities against Escherichia coli, Salmonella muenchen and Salmonella typhimurium with MIC values ranging from 3.12 to 25 μg/mL.
Antioxidant potency and GC-MS composition of Origanum majorana Linn
Pak J Pharm Sci 2019 Sep;32(5):2117-2122.PMID:31813878doi
The methanolic extract of the leaves of Origanum majorana L., was screened for its antioxidant potential and chemical composition. Apart from high total phenolic, flavonoid and antioxidant contents, significant free radical scavenging ability was observed as assessed by the free radical scavenging assays viz., 2,2-Diphenyl-1-picryl hydrazyl, Ferric thiocyanate, Thiobarbituric acid, Ferric reducing antioxidant power and ABTS assays. The GC-MS analysis of the methanolic extract detected the presence of seven compounds - 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 3,9,9a-tris (acetyloxy)-3-[(acetyloxy)methyl]-2-chloro-1,1a,1b,2,3,4,4a,7a,7b,8,9,9a-dodecahydro-4a,7b-dihydroxy-1,1,6,8-tetrame-thyl-,[1aR-(1aa,1ba,2a,3a,4aa,7aa,7ba,8a,9a,9aa)]-; Pentacosanoic Acid, methyl ester; 10-Octadecenoic acid, methyl ester; 1,2,4-Trioxolane-2-octanoic acid, 5-Octyl-, methyl ester; Oleoyl chloride; Docosanedioic acid, dimethyl ester and Ethyl iso-allocholate.
Chemical composition of the fatty oils of the seeds of Cleome viscosa accessions
Nat Prod Commun 2012 Oct;7(10):1363-4.PMID:23157011doi
Fatty oils of the seeds of Cleome viscosa accessions from Delhi, Jaipur, Faridabad, Surajkund and Hyderabad were methylated and analyzed by GC and GC-MS.The major fatty acids, identified as their methyl esters, of the oils from these five locations were palmitic acid (10.2-13.4%), stearic acid (7.2-10.2%), oleic acid (16.9-27.1%) and linoleic acid (47.0-61.1%). In addition, palmitoleic acid,octadec-(11E)-enoicacid, arachidic acid, eicosa-(11Z)-enoic acid, linolenic acid, heneicosanoic acid, behenic acid, lignoceric acid, Pentacosanoic Acid, hexacosanoic acid, 12-oxo-stearic acid, and the alkanes tetracosane, pentacosane, hexacosane, heptacosane, octacosane, nonacosane, triocontane, hentriacontane and dotriacontane, were also identified as minor and trace constituents in some of these oils.
A New Alkenylmethylresorcinol from the Fruits of Ardisia kivuensis
Nat Prod Commun 2016 May;11(5):661-2.PMID:27319144doi
The phytochemical study of the MeOH extract from the fruits of Ardisia kivuensis was carried out using repeated silica gel column chromatography followed by Sephadex LH-20 to afford a new alkenylmethylresorcinol, ardisinol III (1) along with three known compounds, oleanolic acid, β-sitosterol and Pentacosanoic Acid. The structure of 1 was elucidated using spectroscopic analysis (NMR and MS), and comparison with published data. Compound 1 had weak antioxidant activity (IC50 109.8 μg/mL) while other compounds were not active as compared to L-ascorbic acid (IC50 3.9 μg/mL).