Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

qq在线咨询
Home >> Peptides

Peptides(肽)

  1. Cat.No. 产品名称 Information
  2. GA20245 (Lys²²)-Amyloid β-Protein (1-42) The Italian mutation (E22K) aggregates more rapidly than the wild-type sequence.
  3. GA20244 (Lys²²)-Amyloid β-Protein (1-40) The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.
  4. GA20242 (Lys¹⁵)-Amyloid β-Protein (15-21)

    Β淀粉样肽改造多肽-[LYS15]-AMYLOIDΒ-PROTEIN(15-21)

     KKLVFFA contains the KLVFF sequence, which is the minimum sequence binding the full-length amyloid β-protein. It showed improved water solubility compared with KLVFF (H-3682). It can be used as a labeled probe for screening defined sequences in the full-length amyloid β-protein.
  5. GA20229 (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) 是一种特异性的神经肽 Y Y1 受体激动剂。
  6. GA20221 (Hyp³)-Bradykinin

    [Hyp3]-缓激肽

     (Hyp³)-缓激肽，天然存在的肽激素，是一种缓激肽受体激动剂。
  7. GA20205 (H-Cys-Gly-OH)₂

    (Cys-Gly)2, (H-Cys-Gly-OH)2, NSC 333711

     NSC333711. Besides its reduced form, this product of glutathione metabolism is found in plasma.
  8. GA20201 (Gly²⁸,Cys³⁰)-Amyloid β-Protein (1-30) amide
  9. GA20200 (Gly²²)-Amyloid β-Protein (1-42) The arctic mutant of amyloid β peptide 1-42, in which Glu²² is substituted by Gly, is distinctly more amyloidogenic than the wild-type Aβ 1-42.
  10. GA20199 (Gly²²)-Amyloid β-Protein (1-40) The highly neurotoxic arctic mutant (E22G) of Aβ has been used to study the mechanisms underlying the formation of soluble and insoluble β-amyloid aggregates. As the wild-type Aβ, the arctic mutant preferably assembles in the presence of GM1 ganglioside.
  11. GA20198 (Gly²¹)-Amyloid β-Protein (1-42) The Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. A21G is pathogenic as it is degraded significantly more slowly by neprilysin than WT Abeta42.
  12. GA20197 (Gly²¹)-Amyloid β-Protein (1-40) Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant.
  13. GA20195 (Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) (Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human)是一种有效的选择性神经肽 Y Y5 受体激动剂，与 hY5 受体结合的 IC50 为 0.24 nM。
  14. GA20186 (Gln⁹)-Amyloid β-Protein (1-40)
  15. GA20184 (Gln²²,Asn²³)-Amyloid β-Protein (1-40) Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.
  16. GA20183 (Gln²²)-Amyloid β-Protein (1-42) The Dutch mutation (E22Q) aggregates more readily than the wild-type sequence. The resulting fibrils show increased neurotoxicity.
  17. GA20182 (Gln²²)-Amyloid β-Protein (1-40) The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μm, whereas WT Aβ 1-40 and the Italian mutant E22K (H-6698) showed no effect.
  18. GA20181 (Gln¹¹)-Amyloid β-Protein (1-28)
  19. GA20164 (D-Trp¹²,Tyr³⁴)-pTH (7-34) amide (bovine) (D-TrpΌ²,Tyr³⁴)-pTH (7-34) amide (bovine) 是一种有效的竞争性甲状旁腺激素 (PTH) 拮抗剂，在牛肾皮质膜中的 Ki 值为 69 nM。
  20. GA20096 (Des-Glu²²)-Amyloid β-Protein (1-42) The Osaka (E22delta) mutation of Amyloid β promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity.
  21. GA20095 (Des-Glu²²)-Amyloid β-Protein (1-40) The Osaka mutation was the first deletion-type mutation to be identified in APP and Aβ. The Aβ E22delta mutant is more resistant to degradation by two major Aβ-degrading enzymes, neprilysin and insulin-degrading enzyme. Synthetic mutant Aβ showed unusual aggregation properties with enhanced oligomerization but no fibrillization. It also inhibited hippocampal long-term potentiation more efficiently than wild-type Aβ. A transgenic mouse model containing APP with the E693delta mutation has been developed. APP(OSK)-Tg mice exhibit intraneuronal Aβ E22delta oligomers and memory impairment as early as eight months of age.
  22. GA20094 (Des-Cys¹,cyclo(Ser²-Asu⁷))-Calcitonin (eel)

    依降钙素

     Elcatonin, also known as carbocalcitonin, is the aminosuberic acid analog of eel calcitonin. It has all the biological properties of the corresponding natural calcitonin (H-2255). The substitution of the disulfide bond of natural calcitonins with an ethylene bridge in 1-7 N-terminal position gives elcatonin greater stability and excellent tolerability when used in vivo.
  23. GA20054 (Cys⁴⁷)-HIV-1 tat Protein (47-57) (Cys⁴⁷)-HIV-1 tat 蛋白 (47-57) 具有膜易位功能，可用于衍生磁性药物的表面并大大促进其被靶细胞吸收。
  24. GA20053 (Cys²⁶)-Amyloid β-Protein (1-40) Aβ40 S26C has been used for generating the covalently linked Aβ40 homodimer. Dimerization can be easily reverted by reducing the soluble dimer with thiols as β-mercaptoethanol. Aβ40 S26C is perfectly suited for labeling with fluorescent tags
  25. GA20052 (Cys²⁶)-Amyloid β-Protein (1-40) (Dimer) Dimer of H-7402.
  26. GA20050 (Cys⁰)-Amyloid β-Protein (1-40) Cys-Aβ1-40 can be easily and selectively modified, labeled, coupled to carriers e.g. by maleimide chemistry without affecting the sequences involved in fibril formation. The free mercapto moiety of the peptide adheres to gold surfaces.
  27. GA20045 (Asp³⁷)-Amyloid β-Protein (1-42) The G37D mutant does not show the aggregation behavior of WT Abeta42 nor its neurotoxicity.
  28. GA20042 (Asn⁷)-Amyloid β-Protein (1-40) The Tottori (D7N) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers.
  29. GA20041 (Asn⁶⁷⁰,Sta⁶⁷¹,Val⁶⁷²)-Amyloid β/A4 Protein Precursor₇₇₀ (662-675) Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. This new peptide represents a potent substrate analog inhibitor of APP β-secretase with IC?? = 30 nM.
  30. GA20040 (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)

    Β-基质分泌酶Ⅱ

     This peptide substrate corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase activity.
  31. GA20039 (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675) SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, therefore referred to as the 'Swedish' mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products.
  32. GA20038 (Asn²³)-Amyloid β-Protein (1-40) The Iowa (D23N) mutant of Aβ 40 considerably more rapidly assembles in solution to form fibrils than the WT Aβ sequence. These fibrils also show a different structure, which could be responsible for their increased toxicity.
  33. GA20030 (Arg⁶)-Amyloid β-Protein (1-40) The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His? by Arg influences the structure of the Cu(II) complex formed by Aβ peptides.
  34. GA20029 (Arg¹³)-Amyloid β-Protein (1-40) H13R, a mutation in the metal-binding region of Abeta reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.
  35. GA20024 (7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40) Amyloid β-protein (1-40) that is N-terminally modified with the fluorescent dye (7-diethylaminocoumarin-3-yl)carbonyl (DAC or DEAC). This derivative can be utilized to assess the binding properties of amyloid β-protein (1-40) for various membranes since it behaves very similar to the native peptide. In aqueous environments the fluorophore is almost non-fluorescent whereas binding to membranes results in an increase in fluorescence intensity (Λex = 430 nm, Λem = 470 nm). Increases in the GM1 ganglioside and cholesterol content in the lipid bilayers facilitated the binding of this peptide. For phosphatidylcholine and phosphatidylserine no affinity was observed.
  36. GC45592 Urotensin I (white sucker) (trifluoroacetate salt) A peptide
  37. GC45591 Urocortin III (mouse) (trifluoroacetate salt) A neuropeptide hormone
  38. GC45590 Urocortin III (mouse) (free acid) (trifluoroacetate salt)  
  39. GC45589 Urocortin III (human) (trifluoroacetate salt) A neuropeptide hormone
  40. GC45588 Urocortin II (mouse) (trifluoroacetate salt) A neuropeptide hormone
  41. GC45576 TFLLR-NH2 (trifluoroacetate salt) A peptide agonist of PAR1
  42. GC45565 Semax

    脑力肽

     A synthetic peptide with neuroprotective, analgesic, and anxiolytic properties
  43. GC45541 PAR3 (1-6) amide (human) (trifluoroacetate salt)

    Proteinase-Activated Receptor 3, TFRGAP-NH2

     A peptide agonist of PAR1 and PAR2
  44. GC45529 Nonapeptide-1 (acetate)

    Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, MPFRWFKPV-NH2, 153N-6

     An MC1R antagonist
  45. GC45509 Melanocyte-Stimulating Hormone Release-Inhibiting Factor (trifluoroacetate salt)

    MIF-1, MSH-R-IF

     A tripeptide with diverse biological activities
  46. GC45490 Kisspeptin-54 (human) (trifluoroacetate salt)

    Metastin (human)

     A peptide ligand of GPR54
  47. GC45489 K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

    Histone H2BK-Biotin (108-125), K(Biotin)-W-Histone H2B (108-125), K(Biotin)WKHAVSEGTKAVTKYTSSK

     A biotinylated peptide fragment of histone H2B
  48. GC45485 Histone H4R3Me2s (1-21)-GGK-biotin (trifluoroacetate salt)

    Ac-SG-R(me2s)-GKGGKGLGKGGAKRHRKV-GGK(Biotin), Arg(Me2s)3-Histone H4 (1-21)-GGK(Biotin), Histone H4 (1-21) (Arg3me2s)

     A biotinylated peptide fragment of histone H4
  49. GC45484 Histone H3K9Me3 (3-17) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    H-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me3)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-OH, H3K9me3, Histone H3 (3-17) (Lys9me3), Lys(Me3)9-Histone H3 (3-17), TKQTAR-K(Me3)-STGGKAPR

     A peptide fragment of histone H3
  50. GC45483 Histone H3K9Me2 (3-17) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    Histone H3 (3-17) (Lys9me2), H-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me2)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-OH, Lys(Me2)9-Histone H3 (3-17), TKQTAR-K(Me2)-STGGKAPR

     A peptide fragment of histone H3
  51. GC45482 Histone H3K9Me1 (3-17) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    Histone H3 (3-17) (Lys9me1), Lys(Me1)9-Histone H3 (3-17), TKQTAR-K(Me1)-STGGKAPR

     A peptide fragment of histone H3

Items 1301 to 1350 of 2526 total

per page
  2. 25
  3. 26
  4. 27
  5. 28
  6. 29

Set Descending Direction