Phenethylbromide
(Synonyms: beta-溴代苯乙烷) 目录号 : GC44623
An Analytical Reference Standard
Cas No.:103-63-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Phenethylbromide is an analytical reference material that is structurally categorized as an organobromide. It is used in the synthesis of a variety of compounds, including fentanyl. Phenethylbromide is combined with 4-piperidinone to produce N-phenethyl-4-piperidone, which, as a precursor in the synthesis of fentanyl , is scheduled as a List I chemical in the United States. Phenethylbromide may be found as in impurity in samples of fentanyl produced using this pathway.
| Cas No. | 103-63-9 | SDF | |
| 别名 | beta-溴代苯乙烷 | ||
| Canonical SMILES | BrCCC1=CC=CC=C1 | ||
| 分子式 | C8H9Br | 分子量 | 185.1 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.4025 mL | 27.0124 mL | 54.0249 mL |
| 5 mM | 1.0805 mL | 5.4025 mL | 10.805 mL |
| 10 mM | 0.5402 mL | 2.7012 mL | 5.4025 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
A new procedure for labeling alkylbenzenes with [18F]fluoride
Int J Rad Appl Instrum A 1991;42(11):1043-7.PMID:1667310DOI:10.1016/0883-2889(91)90008-o.
A new procedure for labeling alkylbenzenes with no-carrier-added (nca) [18F]fluoride is reported. This will allow the use of [18F]-for-nitro aromatic nucleophilic displacement reaction for labeling aromatic compounds with no activating groups on the benzene ring. The new procedure involves (A) the [18F]-for-nitro displacement reaction on nitrophenones, and (B) the reduction of [18F]fluorophenones with triethylsilane and trifluoroacetic acid to alkylfluorobenzenes. The desired 18F-labeled alkylbenzenes were prepared in a synthesis time of 1 h with a radiochemical yield of 20% at end-of-synthesis. The procedure has been successfully applied to the synthesis of 18F-labeled alkylating agents, such as 4-[18F]fluorophenethyl bromide, 4, and 4-[18F]fluorophenbutyl chloride, 5. Using the reaction of piperidine and 4 as a model, the potential use of Phenethylbromide 4 for labeling biologically important amines was examined. Initial results indicated that the desired alkylated piperidine was formed in low yields (less than 5%) due to the conversion of halide 4 to [18F]fluorostyrene (greater than 85%) under basic conditions. The new procedure provides an easy method of labeling alkylbenzenes with fluorine-18.