Phenothrin (Sumithrin)
(Synonyms: 苯醚菊酯) 目录号 : GC32253
苯醚菊酯 (Sumithrin) 是一种合成拟除虫菊酯，可杀死成年跳蚤和蜱虫。
Cas No.:26002-80-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Phenothrin is a synthetic pyrethroid that kills adult fleas and ticks. It has also been used to kill head lice in humans.
| Cas No. | 26002-80-2 | SDF | |
| 别名 | 苯醚菊酯 | ||
| Canonical SMILES | O=C(C1C(C)(C)C1/C=C(C)\C)OCC2=CC=CC(OC3=CC=CC=C3)=C2 | ||
| 分子式 | C23H26O3 | 分子量 | 350.45 |
| 溶解度 | DMSO : 100 mg/mL (285.35 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8535 mL | 14.2674 mL | 28.5347 mL |
| 5 mM | 0.5707 mL | 2.8535 mL | 5.7069 mL |
| 10 mM | 0.2853 mL | 1.4267 mL | 2.8535 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Evaluation of the genotoxicity of the pyrethroid insecticide Phenothrin
Mutat Res Genet Toxicol Environ Mutagen 2014 Aug;770:1-5.PMID:25344157DOI:10.1016/j.mrgentox.2014.05.001.
Phenothrin, a synthetic pyrethroid compound, is widely used to control agricultural and household insects, as well as to eliminate human louse infestation. Toxicity studies on the direct DNA-damaging effect of Phenothrin are lacking. We therefore investigated whether Phenothrin exposure can lead to increased DNA damage in vitro in human peripheral blood lymphocytes and in human hepatocytes. Genotoxicity was evaluated by means of the comet assay modified with formamidopyrimidine DNA-glycosylase post-treatment for the detection of oxidative base-damage in DNA. We also assessed the cytotoxic potential of this compound by use of combined fluorescence viability staining. Our results show that Phenothrin induces statistically significant, dose-dependent DNA damage in the absence of marked cytotoxicity at concentrations higher than 20 渭M and 50 渭M in human blood peripheral lymphocytes and hepatocytes, respectively. Oxidative DNA damage could also be detected in the two cell types, although this did not reach statistical significance. These findings provide evidence of the DNA-damaging potential of Phenothrin and call for additional studies to reveal the genotoxic properties of this pyrethroid. The observations also point at the importance of using caution when considering the use of Phenothrin.
Phenothrin lotion, the latest recruit in the battle against headlice: the results of two controlled comparative studies
J R Soc Health 1991 Apr;111(2):47-50.PMID:1903813DOI:10.1177/146642409111100202.
One hundred and one subjects with head louse infestation were entered into two separate studies, in which a Phenothrin aqueous/alcoholic lotion was compared to a carbaryl lotion and a malathion lotion. Fifty subjects were treated with a single application of the Phenothrin lotion, 28 with the carbaryl lotion and 23 with the malathion lotion. In the comparative study of the Phenothrin and malathion lotions an inspection on the day following treatment showed no live lice remained, but that six of the subjects treated with malathion lotion still had evidence of viable eggs (p less than 0.05). In one subject viable eggs were still evident at two weeks post-treatment. There were no cases, however, of live lice or viable eggs at four weeks post-treatment. Mild cutaneous side-effects were reported in five subjects, the incidence of which was not significantly different by treatment group. One subject in the Phenothrin and carbaryl lotion comparative study had evidence of live lice at one week post-treatment with Phenothrin lotion. This subject received no further treatment and was clear of both live lice and viable eggs at subsequent visits. A separate case of live lice infestation was found at two weeks post-treatment in a subject treated with Phenothrin lotion and at four weeks post-treatment in two subjects treated with carbaryl lotion. As these subjects were free of live lice infestation at previous follow-up visits it was highly probable that these were cases of re-infestation from another source.(ABSTRACT TRUNCATED AT 250 WORDS)
Exploring the binding mechanism and adverse toxic effects of chiral Phenothrin to human serum albumin: Based on multi-spectroscopy, biochemical and computational approach
Spectrochim Acta A Mol Biomol Spectrosc 2022 Dec 5;282:121659.PMID:35930945DOI:10.1016/j.saa.2022.121659.
To understand the binding mechanism of a mixture of chiral Phenothrin with human serum albumin (HSA), we used multi-spectroscopy, including steady-state fluorescence spectroscopic titration, three-dimensional fluorescence spectroscopy, circular dichroism, and FTIR spectra to explore the precise interactions between the complex. Based on the modified Stern-Volmer equation, the binding constant (Ka) was calculated under three temperatures, which revealed that Phenothrin interacts with HSA through a static quenching mechanism. The thermodynamic parameters including enthalpy change (螖H) and entropy change (螖S) were determined by fitting the experimental data with van't Hoff equation, which indicates that electrostatic force and hydrogen bonds dominate the interplay in the phenothrin-HSA complex. Circular dichroism and FTIR showed the addition of Phenothrin changed the secondary structure of proteins, in which the 伪-helicity decreased from 52.37% in free HSA to 50.02%. The esterase-like activity was reduced with the increase of Phenothrin concentration, which may be attributed to the perturbated senior structure of HSA. Competitive displacement experiments confirmed that Phenothrin inserted into the subdomain IIA (site I) of HSA. Several computational approaches such as molecular docking, frontier molecular orbital analysis, and electrostatic potential analysis were utilized to probe into the binding mode of the phenothrin-HSA complex. The binding behaviors of the chiral Phenothrin mixture differed during the complexation. In conclusion, both the experimental and theoretical investigations provide useful information for better understanding and reducing the potential deleterious effects of the chiral Phenothrin mixture on human long-term physio-pathological status.
Analysis of Phenothrin and Its Metabolite 3-Phenoxybenzoic Acid (PBA) in Agricultural Products by GC and Ion-Trap GC/MS
J Food Prot 1997 Mar;60(3):305-308.PMID:31195473DOI:10.4315/0362-028X-60.3.305.
A sensitive method for analysis of Phenothrin and its metabolite 3-phenoxybenzoic acid (PBA) in agricultural products by gas chromatography with electron capture detection (ECD-GC) and ion-trap gas chromatography/mass spectrometry (GC/MS) with chemical ionization (Cl) was investigated. After Phenothrin in vegetables, fruits, potatoes, starches, and tea had been extracted with acetone, or in cereals and beans had been extracted with acetonitrile followed by Florisi! column chromatography, it was reextracted into n-hexane. PBA was determined by ECD-GC after esterification with hexafluoroisopropyl alcohol (HFIP) and diisopropylcarbodiimide (DIC). Phenothrin was determined by monitoring its molecular ion peak using ion-trap GC/MS and was confirmed by observing its spectral pattern. The detection limit for Phenothrin by ECD-GC and ion-trap GC/MS by this method was 0.01 ppm. The detection limit for PBA by ECD-GC was 0.001 ppm. When Phenothrin and PBA were added to samples at 0.2 and 1.0 ppm, the recoveries of Phenothrin in each agricultural product ranged between 60.2 and 88.5% and those of PBA ranged between 37.8 and 89.5%. An actual-conditions surveillance analysis of six agricultural products imported from October to December 1994 indicated no Phenothrin, but PBA was detected in all products.
Comparison of Phenothrin mousse, Phenothrin lotion, and wet-combing for treatment of head louse infestation in the UK: a pragmatic randomised, controlled, assessor blind trial
F1000Res 2014 Jul 10;3:158.PMID:25254106DOI:10.12688/f1000research.2026.1.
In this investigation of effectiveness of an alternative pediculicide dosage form, we recruited 228 children and 50 adult participants from Bedfordshire, UK, to a randomised, controlled, assessor blind trial comparing two insecticide products with mechanical removal of lice as a control group. Participants using insecticide were treated with either the investigative 0.5% Phenothrin mousse, for 30 minutes, or 0.2% Phenothrin lotion, for 2 hours as the reference product. Both treatments were applied only once, followed by shampoo washing. Those treated by wet-combing with conditioner were combed 4 times over 12 days. Parents/carers carried out the treatments to mimic normal consumer use. The outcome measure was the absence of lice, 14 days after treatment for the insecticides, and up to 14 days after completion of combing. Intention to treat analysis of the outcomes for 275 participants showed success for Phenothrin mousse in 21/105 (20.0%), in 23/107 (21.5%) for Phenothrin lotion, and in 12/63 (19.1%) for wet-combing. People receiving mousse were 1.07 (95% CI, 0.63 to 1.81) times more likely to still have lice after treatment compared with those treated with lotion. The group of participants who received the wet combing treatment were 1.13 (95% CI, 0.61 to 2.11) times more likely to still have lice after the treatment. None of the treatments was significantly (p < 0.05) more effective than any other. This study was carried out in an area where moderate resistance to Phenothrin was demonstrated after the study by using a bioassay. Analysis of post treatment assessments found that failure of insecticides to kill louse eggs had influenced the outcome.