Phenylephrine HCl
(Synonyms: 盐酸去氧肾上腺素; (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride) 目录号 : GC11272
Phenylephrine HCl（盐酸去氧肾上腺素）是一种选择性的α1-肾上腺素能受体激动剂。
Cas No.:61-76-7
Sample solution is provided at 25 µL, 10mM.
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Phenylephrine HCl is a selective α1-adrenergic receptor agonist[1]. Phenylephrine HCl is commonly used to treat symptoms such as hypotension and nasal congestion[2]. Phenylephrine HCl can induce cardiac hypertrophy[3].
In vitro, phenylephrine HCl (0.1, 1, 10μM) treated cardiac fibroblasts for 48h stimulated cell proliferation in a dose-dependent manner, upregulated calcineurin (CaN) levels, and caused nuclear factor of activated T cells 3 (NFAT3) nuclear translocation[4].
In vivo, phenylephrine HCl (0.001-10μM) was injected into the alveolar cavity to treat rats with high tidal volume (HVT) mechanical ventilation-induced lung injury, which increased the alveolar fluid clearance (AFC) of rats and accelerated the absorption of pulmonary edema[5].
References:
[1] Bouchelouche K, Andersen L, Alvarez S, et al. Increased contractile response to phenylephrine in detrusor of patients with bladder outlet obstruction: effect of the α1A and α1D-adrenergic receptor antagonist tamsulosin[J]. The Journal of urology, 2005, 173(2): 657-661.
[2] Eccles R. Substitution of phenylephrine for pseudoephedrine as a nasal decongeststant. An illogical way to control methamphetamine abuse[J]. British journal of clinical pharmacology, 2007, 63(1): 10-14.
[3] Zheng J, Tian J, Wang S, et al. Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway[J]. European Journal of Pharmacology, 2020, 883: 173386.
[4] Wang J, Wang Y, Zhang W, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway[J]. development, 2016.
[5] Li N, Gu X, Li W, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury[J]. Chinese Medical Sciences Journal, 2013, 28(1): 1-6.
Phenylephrine HCl（盐酸去氧肾上腺素）是一种选择性的α1-肾上腺素能受体激动剂[1]。Phenylephrine HCl常用于治疗低血压、鼻塞等症状[2]。Phenylephrine HCl可以诱导心脏肥大[3]。
在体外，Phenylephrine HCl（0.1, 1, 10μM）处理心脏成纤维细胞48h，以剂量依赖性方式刺激细胞增殖，上调了钙调磷酸酶（CaN）水平，引起了活化T细胞核因子3（NFAT3）核转位[4]。
在体内，Phenylephrine HCl（0.001-10μM）通过注入肺泡腔治疗高潮气量（HVT）机械通气诱导的肺损伤大鼠，可增加大鼠的肺泡液清除率（AFC）并加速肺水肿的吸收[5]。
| Cell experiment [1]: | |
Cell lines | Cardiac fibroblasts (CFs) |
Preparation Method | Growth-arrested CFs were stimulated with various concentrations of Phenylephrine HCl (0.1, 1, 10μM) for 48h. Optical density with MTT labeling. |
Reaction Conditions | 0.1, 1, 10μM; 48h |
Applications | Phenylephrine HCl stimulates CFs proliferation in a dose-dependent manner. |
| Animal experiment [2]: | |
Animal models | Wistar rats |
Preparation Method | A total of 170 male Wistar rats are randomLy allocated into 17 groups (n=10) using random number tables. Short-term (40min) mechanical ventilation with high tidal volume is performed to induce lung injury, impair active Na+ transport and lung liquid clearance in the rats. Unventilated rats serves as controls. To demonstrate the effect of phenylephrine on alveolar fluid clearance, Phenylephrine HCl at different concentrations (0.001, 0.01, 0.1, 1, and 10μM) is injected into the alveolar space of the high tidal volume (HVT) ventilated rats. |
Dosage form | 0.001, 0.01, 0.1, 1, and 10μM; injected into the alveolar space |
Applications | Phenylephrine could increase the alveolar fluid clearance (AFC) in HVT-ventilated rats and accelerate the absorption of pulmonary edema. |
References: | |
| Cas No. | 61-76-7 | SDF | |
| 别名 | 盐酸去氧肾上腺素; (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride | ||
| 化学名 | 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride | ||
| Canonical SMILES | CNCC(C1=CC(=CC=C1)O)O.Cl | ||
| 分子式 | C9H13NO2.HCl | 分子量 | 203.67 |
| 溶解度 | ≥ 10.1835mg/mL in DMSO | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.9099 mL | 24.5495 mL | 49.099 mL |
| 5 mM | 0.982 mL | 4.9099 mL | 9.8198 mL |
| 10 mM | 0.491 mL | 2.455 mL | 4.9099 mL |
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| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
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| % DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度： mg/ml；
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Quality Control & SDS
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- Purity: >99.50%
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