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Phosphatidic Acids (ammonium salt)

目录号 : GC91806

Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis.

Phosphatidic Acids (ammonium salt) Chemical Structure

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25 mg
¥1,498.00
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50 mg
¥2,646.00
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Sample solution is provided at 25 µL, 10mM.

Description

Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis.[1] It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple routes, including the glycerol-3 phosphate and dihydroxyacetone phosphate pathways, enzymatic conversion of phosphatidylcholine by phospholipase D, and acetylation of lysophosphatidic acid by lysoPA-acyltransferase, among others.2,3 It has roles in shaping cellular membranes, cellular signaling, vesicle fission and fusion, as well as mitochondrial division and fusion. It stimulates respiratory burst in neutrophils independent of diacylglycerol and activates monoacylglycerol acyltransferase, phospholipase C (PLC), Ras, and phosphatidylinositol 4-phosphate (PIP4) kinase in several cell lines. This product contains phosphatidic acid molecular species with primarily C16:0 and C18:1 fatty acyl chain lengths.

References:
[1].Athenstaedt, K., and Daum, G.Phosphatidic acid, a key intermediate in lipid metabolismEur. J. Biochem.266(1)1-16(1999).
[2].Járai, Z., Wagner, J.A., Goparaju, S.K., et al.Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized miceHypertension35679-684(2000).
[3].Kameoka, S., Adachi, Y., Okamoto, K., et al.Phosphatidic acid and cardiolipin coordinate mitochondrial dynamicsTrends Cell Biol.28(1)67-76(2018).

化学性质

Cas No. N/A SDF Download SDF
分子式 C39H72O8P•NH4 (for oleoyl) 分子量 718
溶解度 Chloroform: soluble,Ether: soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.3928 mL 6.9638 mL 13.9276 mL
5 mM 0.2786 mL 1.3928 mL 2.7855 mL
10 mM 0.1393 mL 0.6964 mL 1.3928 mL
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