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Piericidin A

(Synonyms: 粉蝶霉素A,AR 054, Shaoguanmycin B, SN 198E) 目录号 : GC13776

A potent inhibitor of mitochondrial complex I

Piericidin A Chemical Structure

Cas No.:2738-64-9

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1mg (12.03 mM * 200 μL in Ethanol)
¥4,050.00
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Sample solution is provided at 25 µL, 10mM.

Description

Piericidin A is a mitochondrial complex I inhibitor.

Complex I, also known as NADH:ubiquinone oxidoreductase, catalyzes the transfer of electrons from NADH to ubiquinone as part of the respiratory chain resulting in ATP generation.

In vitro: Previous study found that piericidin A could inhibit the electron transport system at two sites. Piericidin A specifically reacted at very low concentrations at a site near the reduced NADH dehydrogenase. At high concentrations, piericidin A inhibited the succinic dehydrogenase system, and the inhibition could be partially reversed by coenzyme Q. Moreover, it was found that both the succinate and NADH oxidase system were inhibited at high levels of piericidin A [1].

In vivo: Animal study was performed to evaluate the effect of piericidin A and antagonistic effect of vitamin K3 on respiration, blood pressure and heart rate in rats. Results showed that 0.167 mg/kg of piericidin A increased the respiratory rate and the lowered blood pressure rapidly. Furthermore, vitamin K3 (10-40 mg/kg) could restore the responses to piericidin A in rats [2].

Clinical trial: Up to now, piericidin A is still in the preclinical development stage.

References:
[1] Jeng M, Hall C, Crane FL, Takahashi N, Tamura S, Folkers K.  Inhibition of mitochondrial electron transport by piericidin A and related compounds. Biochemistry. 1968 Apr;7(4):1311-22.
[2] Mitsui T et al.  Studies on piericidin antagonistic effect of vitamin K3 on the respiratory chain of insects and mammals in the presence of piericidin A. Agricultural and Biological Chemistry Vol. 34 (1970) No. 7 P 1101-1109

化学性质

Cas No. 2738-64-9 SDF
别名 粉蝶霉素A,AR 054, Shaoguanmycin B, SN 198E
化学名 2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol
Canonical SMILES COC1=C(O)C(C)=C(C/C=C(C)/C/C=C/C(C)=C/[C@H]([C@@H](O)/C(C)=C/C)C)N=C1OC
分子式 C25H37NO4 分子量 415.6
溶解度 Soluble in DMSO, Soluble in DMF, Soluble in Ethanol, Soluble in Methanol 储存条件 Store at -80°C,protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 2.4062 mL 12.0308 mL 24.0616 mL
5 mM 0.4812 mL 2.4062 mL 4.8123 mL
10 mM 0.2406 mL 1.2031 mL 2.4062 mL
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