Piperacetazine
(Synonyms: 乙酰哌普嗪) 目录号 : GC33670
A typical antipsychotic
Cas No.:3819-00-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Piperacetazine is a typical antipsychotic.1 It inhibits spontaneous motor activity and responding for food in rats, as well as potentiates hexobarbital-induced narcosis in mice. It also inhibits lysosome acidification, as well as viral entry (IC50 = <8.5 ?M), in Ebola-infected Huh7 cells.2 Formulations containing piperacetazine have been used in the treatment of schizophrenia.
1.Pitman-MoorePiperacetazine (Quide tablets)Clin. Pharmacol. Ther.10(5)749-754(1969) 2.Dyall, J., Nelson, E.A., DeWald, L.E., et al.Identification of combinations of approved drugs with synergistic activity against Ebola virus in cell culturesJ. Infect. Dis.218(Suppl 5)S672-S678(2018)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4356 mL | 12.1782 mL | 24.3564 mL |
| 5 mM | 0.4871 mL | 2.4356 mL | 4.8713 mL |
| 10 mM | 0.2436 mL | 1.2178 mL | 2.4356 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。