Piperonyl butoxide (ENT-14250)
(Synonyms: 增效醚) 目录号 : GC32136
An insecticide synergist
Cas No.:51-03-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Piperonyl butoxide is a synergist used to enhance the activity of insecticides, including pyrethrin insecticides, through inhibition of cytochrome P450 enzymes (CYPs).1,2 It increases the toxicity of the pyrethroid insecticide deltamethrin to field-collected, deltamethrin-resistant strains of the bed bug C. lectularius by 40- to 176-fold when used at a concentration of 50 μg/μL.2 Piperonyl butoxide also increases the toxicity of the organotin insecticide Plictran to fourth instar larvae of susceptible strains of the cotton leafworm S. littoralis (LD50s = 0.78 and 40 μg/larva with and without piperonyl butoxide, respectively), as well as field strains (LD50s = 0.015 and 1.1 μg/larva with and without piperonyl butoxide, respectively).3 It is not toxic to the freshwater invertebrates H. azteca, C. tentans, and L. variegatus (LC50s = 530, 2,740, and 3,540 μg/L, respectively) and reduces the toxicity of the organophosphate pesticides diazinon , chlorpyrifos , and azinphos-methyl, which require activation by CYP enzymes in these organisms.1 Formulations containing piperonyl butoxide have been used for the control of agricultural, household, and veterinary pests.
1.Ankley, G.T., and Collyard, S.A.Influence of piperonyl butoxide on the toxicity of organophosphate insecticides to three species of freshwater benthic invertebratesComp. Biochem. Physiol.110(2)149-155(1995) 2.Romero, A., Potter, M.F., and Haynes, K.F.Evaluation of piperonyl butoxide as a deltamethrin synergist for pyrethroid-resistant bed bugsJ. Econ. Entomol.102(6)2310-2315(2009) 3.Radwan, H.S.A., Riskallah, M.R., and El-Keie, I.A.Synergistic effects on the toxicity of organotins on cotton leafwormsToxicology14(3)193-198(1979)
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9547 mL | 14.7737 mL | 29.5473 mL |
| 5 mM | 0.5909 mL | 2.9547 mL | 5.9095 mL |
| 10 mM | 0.2955 mL | 1.4774 mL | 2.9547 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。