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Plecanatide acetate Sale

(Synonyms: 普卡那肽醋酸盐;醋酸普卡那肽) 目录号 : GC33898

A peptide agonist of the guanylate cyclase C receptor

Plecanatide acetate Chemical Structure

Cas No.:1075732-84-1

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥14,536.00
现货
5mg
¥4,373.00
现货
10mg
¥7,586.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Plecanatide is a peptide agonist of the guanylate cyclase C receptor.1 It stimulates cGMP production in T84 colon cancer cells (EC50 = 170 nM). Plecanatide (10 ppm in the diet) reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67, a marker of cell proliferation, induced by dextran sulfate in cancer-prone Apc+/Min-FCCC mice.2 It suppresses trinitrobenzenesulfonic acid-induced increases in abdominal contractions in a rat model of visceral hypersensitivity when administered at doses of 0.01 and 0.05 mg/kg.3 Formulations containing plecanatide have been used in the treatment of chronic idiopathic constipation.

1.Shailubhai, K., Palejwala, V., Arjunan, K.P., et al.Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitisWorld J. Gastrointest. Pharmacol. Ther.6(4)213-222(2015) 2.Chang, W.-C.L., Masih, S., Thadi, A., et al.Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC miceWorld J. Gastrointest. Pharmacol. Ther.8(1)47-59(2017) 3.Boulete, I.-M., Thai, A., Beaufrand, C., et al.Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat modelsWorld J. Gastroenterol.24(17)1888-1900(2018)

Chemical Properties

Cas No. 1075732-84-1 SDF
别名 普卡那肽醋酸盐;醋酸普卡那肽
Canonical SMILES OC(C)=O.[NDECELCVNV ACTGCL]
分子式 C67H108N18O28S4 分子量 1741.94
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.5741 mL 2.8704 mL 5.7407 mL
5 mM 0.1148 mL 0.5741 mL 1.1481 mL
10 mM 0.0574 mL 0.287 mL 0.5741 mL
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