PLSCR3 Human
目录号 : GP24197Phospholipid Scramblase 3 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Phospholipid scramblase 3; PL scramblase 3; Ca(2+)-dependentphospholipid scramblase 3. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAGYLPP KGYAPSPPPP YPVTPGYPEP ALHPGPGQAP VPAQVPAPAPGFALFPSPGP VALGSAAPFL PLPGVPSGLE FLVQIDQILI HQKAERVETF LGWETCNRYE LRSGAGQPLGQAAEESNCCA RLCCGARRPL RVRLADPGDR EVLRLLRPLH CGCSCCPCGL QEMEVQAPPG TTIGHVLQTW HPFLPKFSIQ DADRQTVLRVVGPCWTCGCG TDTNFEVKTR DESRSVGRIS KQWGGLVREA LTDADDFGLQ FPLDLDVR | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. | ||
| Formulation | PLSCR3 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 10% glycerol and 0.4M urea. | ||
PhospholipidScramblase 3, (PLSCR3) may mediate accelerated ATP-independent bidirectionaltransbilayer migration of phospholipids upon binding calcium ions which resultsin a loss of phospholipid asymmetry in the plasma membrane. PLSCR3may play a key role in the initiation of fibrin clot formation, in theactivation of mast cells and in the recognition of apoptotic and injured cellsby the reticuloendothelial system. In addition, PLSCR3 seems to play a role inapoptosis, throughtranslocation of cardiolipin from the inner to the outer mitochondrial membranewhich promotes BID recruitment and enhances tBid-induced mitochondrial damages.Among the diseases associated with PLSCR3 are brain ischemia, and ischemia.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.