Poncirin

Poncirin is a flavonoid glycoside that has been found in P. trifoliata and has diverse biological activities.^1,2,3,4 It inhibits the growth of SGC-7901 gastric cancer cells when used at concentrations ranging from 5 to 25 ?g/ml.² Poncirin (25-100 ?M) inhibits LPS-induced NF-κB DNA-binding activity, as well as production of nitric oxide (NO) and prostaglandin E₂ in RAW 264.7 cells.³ It reduces the gastric ulcer lesion index in a rat model of HCl/ethanol-induced gastritis when administered at doses of 50 and 100 mg/kg.⁴

1.Mouly, P., Gaydou, E.M., and Auffray, A.Simultaneous separation of flavanone glycosides and polymethoxylated flavones in citrus juices using liquid chromatographyJ. Chromatogr. A800(2)171-179(1998) 2.Zhu, X., Luo, F., Zheng, Y., et al.Characterization, purification of Poncirin from edible Citrus Ougan (Citrus reticulate cv. Suavissima) and its growth inhibitory effect on human gastric cancer cells SGC-7901Int. J. Mol. Sci.14(5)8684-8697(2013) 3.Kim, J.-B., Han, A.-R., Park, E.-Y., et al.Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-κB inactivation in RAW 264.7 macrophage cellsBiol. Pharm. Bull.30(12)2345-2351(2007) 4.Lee, J.-H., Lee, S.-H., Kim, Y.S., et al.Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric diseasePhytother. Res.23(12)1748-1753(2009)