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Porphobilinogen Sale

(Synonyms: 紫質膽素原) 目录号 : GC31575

Porphobilinogen可以作为一种光毒素,神经毒素和代谢毒素。

Porphobilinogen Chemical Structure

Cas No.:487-90-1

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

Porphobilinogen can act as a phototoxin, a neurotoxin, and a metabotoxin. A phototoxin leads to cell damage upon exposure to light. A neurotoxin causes damage to nerve cells and nerve tissues. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels[1].

[1]. Winkelman JW, et al. Neurotoxicity of tetraphenylporphinesulfonate TPPS4 and its relation to photodynamic therapy. Photochem Photobiol. 1987 Nov;46(5):801-7.

Chemical Properties

Cas No. 487-90-1 SDF
别名 紫質膽素原
Canonical SMILES O=C(O)CCC1=CNC(CN)=C1CC(O)=O
分子式 C10H14N2O4 分子量 226.23
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.4203 mL 22.1014 mL 44.2028 mL
5 mM 0.8841 mL 4.4203 mL 8.8406 mL
10 mM 0.442 mL 2.2101 mL 4.4203 mL
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Research Update

PORPHOBILINOGEN

Porphobilinogen

[Porphobilinogen]

The porphobilinogen synthase catalyzed reaction mechanism

Porphobilinogen synthase (PBGS) catalyzes the first common reaction in the biosynthesis of the tetrapyrroles, the asymmetric condensation of two molecules of delta-aminolevulinic acid to form porphobilinogen. There is a variable requirement for an essential active site zinc that necessitates consideration of PBGS as an enzyme that may exhibit phylogenetic diversity in its chemical reaction mechanism. Recent crystal structures suggest reaction mechanisms that involve two covalent Schiff base linkages between adjacent active site lysine residues and each of the two substrate molecules. The reaction appears to stall at a covalently bound almost-product intermediate that is poised for breakdown to product upon binding of a substrate molecule to an adjacent active site and a subsequent conformational change.

[Porphobilinogen]