Precocene II
(Synonyms: 早熟素Ⅱ) 目录号 : GC47969A chromene with anti-juvenile hormone activity
Cas No.:644-06-4
Sample solution is provided at 25 µL, 10mM.
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Precocene II is a chromene that has been found in A. houstonianum and has anti-juvenile hormone activity.1,2,3 It inhibits juvenile hormone biosynthesis in isolated spontaneously active cockroach (P. americana) corpora allata when used at concentrations of 1 mM or higher.1 Precocene II (8 μg/cm2 coating in Petri dish) inhibits development of the corpus allatum in newly eclosed female milkweed bugs and causes allatal regression when applied 120 hours post-eclosion in normally developing females.2 It induces precocious metamorphosis in milkweed bug second-stage nymphs when applied as a coating to Petri dishes at concentrations of 0.4 and 0.7 μg/cm2.3 Precocene II inhibits ovarian development in various insects, including milkweed bugs, cotton stainers, apple maggots, and Mexican bean beetles. Precocene II also inhibits production of the trichothecene mycotoxin 3-acetyldeoxy nivalenol in F. graminearum (IC50 = 1.2 μM) without inhibiting fungal growth.4
1.Pratt, G.E., and Bowers, W.S.Precocene II inhibits juvenile hormone biosynthesis by cockroach corpora allata in vitroNature265(5594)548-550(1977) 2.Bowers, W.S., and Martinez-Pardo, R.Antiallatotropins: Inhibition of corpus allatum developmentScience197(4311)1369-1371(1977) 3.Bowers, W.S., Ohta, T., Cleere, J.S., et al.Discovery of insect anti-juvenile hormones in plantsScience193(4253)542-547(1976) 4.Sakuda, S.Mycotoxin production inhibitors from natural productsMycotoxins60(2)79-86(2010)
| Cas No. | 644-06-4 | SDF | |
| 别名 | 早熟素Ⅱ | ||
| Canonical SMILES | CC1(C)C=CC2=CC(OC)=C(OC)C=C2O1 | ||
| 分子式 | C13H16O3 | 分子量 | 220.3 |
| 溶解度 | DMSO : 100 mg/mL (454.01 mM; ultrasonic and warming and heat to 80°C) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.5393 mL | 22.6963 mL | 45.3926 mL |
| 5 mM | 0.9079 mL | 4.5393 mL | 9.0785 mL |
| 10 mM | 0.4539 mL | 2.2696 mL | 4.5393 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet