Prednisone-d7
(Synonyms: 1,2-Dehydrocortisone-d7) 目录号 : GC47970
A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Prednisone-d7 is intended for use as an internal standard for the quantification of prednisone by GC- or LC-MS. Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities.1 It inhibits paw swelling induced by sodium urate in mice by 86% when administered at a dose of 12 mg/kg.2 Prednisone reduces release of IL-6, monocyte chemoattractant protein-2 (MCP-2), MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis.3 Formulations containing prednisone have been used in the treatment of non-Hodgkin lymphoma as part of CHOP chemotherapy and as anti-inflammatory or immunosuppressive agents.
1.Brownie, A.C.The metabolism of adrenal cortical steroidsThe Adrenal Gland2209-225(1992) 2.Fitzgerald, T.J., Williams, B., and Uyeki, E.M.Effects of antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in micePharmacology6(5)265-273(1971) 3.Ribichini, F., Joner, M., Ferrero, V., et al.Effects of oral prednisone after stenting in a rabbit model of established atherosclerosisJ. Am. Coll. Cardiol.50(2)176-185(2007)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.736 mL | 13.6799 mL | 27.3598 mL |
| 5 mM | 0.5472 mL | 2.736 mL | 5.472 mL |
| 10 mM | 0.2736 mL | 1.368 mL | 2.736 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。