Pregnanediol-3-Glucuronide
(Synonyms: Pregnanediol-3α-Glucuronide) 目录号 : GC41266A metabolite of progesterone
Cas No.:1852-49-9
Sample solution is provided at 25 µL, 10mM.
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Pregnanediol-3-glucuronide (PDG) is the primary urinary metabolite of the steroid hormone progesterone。 [1] Levels of PDG in the urine correlate to levels of progesterone measured in the serum.[1] [2] Analysis of urinary PDG has been used to detect ovulatory and anovulatory menstrual cycles in women as well as to assess the fertility of ovulatory cycles.[3] [4]
Reference:
[1]. O'Connor, K.A., Brindle, E., Holman, D.J., et al. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research. Clin. Chem. 49(7), 1139-1148 (2003).
[2]. Munro, C.J., Stabenfeldt, G.H., Cragun, J.R., et al. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clin. Chem. 37(6), 838-844 (1991).
[3]. Kassam, A., Overstreet, J.W., Snow-Harter, C., et al. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm. Environ. Health Perspect. 104(4), 408-413 (1996).
[4]. Blackwell, L.F., Cooke, D.G., and Brown, S. The use of estrone-3-glucuronide and pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity. Front. Public Health 6:153, (2018).
| Cas No. | 1852-49-9 | SDF | |
| 别名 | Pregnanediol-3α-Glucuronide | ||
| 化学名 | (3α,5β,20S)-20-hydroxypregnan-3-yl, β-D-glucopyranosiduronic acid | ||
| Canonical SMILES | C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@H](C)O)[H])([H])C[C@H](O[C@]5([H])O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)CC1 | ||
| 分子式 | C27H44O8 | 分子量 | 496.6 |
| 溶解度 | 20mg/mL in ethanol | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0137 mL | 10.0685 mL | 20.1369 mL |
| 5 mM | 0.4027 mL | 2.0137 mL | 4.0274 mL |
| 10 mM | 0.2014 mL | 1.0068 mL | 2.0137 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet