Proadrenomedullin (45-92) (human) (trifluoroacetate salt)
(Synonyms: Mid-Regional proADM, Mid-Regional Proadrenomedullin, MR-proADM, MR-proAM, proADM, proAM) 目录号 : GC90290一种来源于前肾上腺髓质素的肽。
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Proadrenomedullin (45-92) (MR-proADM) is a peptide that is comprised of amino acid residues 45-92 of preproadrenomedullin.1 MR-proADM has no effect on precontracted isolated cat pulmonary arterial rings when used at concentrations up to 10 μM, unlike adrenomedullin (1-52) and adrenotensin, which induce relaxation and contraction, respectively.2 Levels of MR-proADM are elevated in the plasma of patients with sepsis and those with cardiovascular disease and positively correlate with disease severity in patients with community-acquired pneumonia.1,3
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.1955 mL | 0.9776 mL | 1.9551 mL |
5 mM | 0.0391 mL | 0.1955 mL | 0.391 mL |
10 mM | 0.0196 mL | 0.0978 mL | 0.1955 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。