Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)
(Synonyms: 丙环定盐酸盐; Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride) 目录号 : GC30946
A muscarinic acetylcholine receptor antagonist
Cas No.:1508-76-5
Sample solution is provided at 25 µL, 10mM.
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Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively).1 It increases fine motor activity counts (ED50 = 1.74 mg/kg) without affecting ambulatory activity in rats in a home-cage activity test.2 Formulations containing procyclidine have been used in the treatment of parkinsonism and extrapyramidal dysfunction.
1.Lazareno, S., Buckley, N.J., and Roberts, F.F.Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cellMol. Pharmacol.38(6)805-815(1990) 2.Sipos, M.L., Burchnell, V., and Galbicka, G.Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in ratsPsychopharmacology147(3)250-256(1999)
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Animal experiment: |
Rats[1] Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes a transient increase in locomotor activity (mainly non-ambulatory fine movements) in adult rats. Locomotor activity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg) altered the activity levels compared to the same doses of Procyclidine administered alone. A one-way ANOVA and subsequent comparisons are also conducted to establish whether the activity levels for each treatment group are different from saline controls. |
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References: [1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48. |
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| Cas No. | 1508-76-5 | SDF | |
| 别名 | 丙环定盐酸盐; Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride | ||
| Canonical SMILES | OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCC3.[H]Cl | ||
| 分子式 | C19H30ClNO | 分子量 | 323.9 |
| 溶解度 | DMSO : 10.66 mg/mL (32.91 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0874 mL | 15.4369 mL | 30.8737 mL |
| 5 mM | 0.6175 mL | 3.0874 mL | 6.1747 mL |
| 10 mM | 0.3087 mL | 1.5437 mL | 3.0874 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet