Home>>Peptides>>Prolactin-Releasing Peptide (1-31) (human)

Prolactin-Releasing Peptide (1-31) (human) Sale

(Synonyms: Human PrRP-31, PrRP(1-31)) 目录号 : GC18366

A neuropeptide involved in regulating food intake

Prolactin-Releasing Peptide (1-31) (human) Chemical Structure

Cas No.:215510-22-8

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500μg
¥2,243.00
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Sample solution is provided at 25 µL, 10mM.

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实验参考方法

Animal experiment:

Rats[1]Groups of rats are injected with either Prolactin Releasing Peptide (1-31) 5 nM or saline. Prolactin Releasing Peptide (1-31), human is dissolved in saline is administered in a total volume of 10 μL. Animals are habituated to the injection procedures by three ICV injections prior to the study to minimize stress in the animals. At 10, 20, 60 minutes following injection, rats are decapitated and trunk blood collected into plastic tubes[1].

References:

[1]. Langmead CJ, et al. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.
[2]. Seal LJ, et al. Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats. Endocrinology. 2000 May;141(5):1909-12.

产品描述

Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake. It is found in the hypothalamus, medulla, and pituitary in rats. PrRP is an agonist of the G-protein coupled receptors GPR10/hGR3 and neuropeptide FF receptor (hNPFF2; Kis = 1 and 19 nM, respectively). It stimulates calcium mobilization in HEK293 cells expressing GPR10 (EC50 = 1.5 nM) and radiolabeled GTPγS binding to membrane homogenates from CHO cells transfected with hNPFF2 (EC50 = 240 nM). PrRP (100 nM) increases the release of gonadotropin-releasing hormone , vasoactive intestinal peptide-, and galanin from rat medial basal hypothalamic explants. It increases plasma levels of luteinizing hormone, follicle stimulating hormone, and testosterone in male rats when administered at an intracerebroventricular dose of 5 nmol. PrRP reduces food intake in fasted rats to 58.4, 53.4, and 55.4% of control levels when administered at doses of 1, 5, and 10 nmol, respectively.

References:
[1]. Seal, L.G., Small, C.J., Shillo, W.S., et al. PRL-releasing peptide inhibits food intake in male rats via the dorsomedial hypothalamic nucleus and not the paraventricular hypothalamic nucleus Endocrinology 142(10), 4236-4243 (2001).
[2].Langmead, C.J., Szekeres, P.G., Chambers, J.K., et al. Characterization of the binding of [125I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor Br. J. Pharmacol. 131(4), 683-688 (2000).
[3]. Engstr?m, M., Brandt, A., Wurster, S., et al. Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors J. Pharmacol. Exp. Ther. 305(3), 825-832 (2003).
[4].Seal, L.J., Small, C.J., Kim, M.S., et al. Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats Endocrinology 141(5), 1909-1912 (2000).

Chemical Properties

Cas No. 215510-22-8 SDF
别名 Human PrRP-31, PrRP(1-31)
化学名 N/A
Canonical SMILES N/A
分子式 C160H252N56O42S 分子量 3664.2
溶解度 Water: 1 mg/ml 储存条件 Store at -20°C
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1 mM 0.2729 mL 1.3646 mL 2.7291 mL
5 mM 0.0546 mL 0.2729 mL 0.5458 mL
10 mM 0.0273 mL 0.1365 mL 0.2729 mL
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