Propafenone-d5 (hydrochloride)
(Synonyms: 盐酸普罗帕酮 D5) 目录号 : GC48612
An internal standard for the quantification of propafenone
Cas No.:1346605-05-7
Sample solution is provided at 25 µL, 10mM.
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Propafenone-d5 is intended for use as an internal standard for the quantification of propafenone by GC- or LC-MS. Propafenone is a class I antiarrhythmic agent.1 It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively).1,2 Propafenone also blocks sodium (INa), potassium (IK), and transient outward potassium currents in various cardiac cells.2,3,4 In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia.5 Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.
1.Delgado, C., Tamargo, J., D., H., et al.Effects of propafenone on calcium current in guinea-pig ventricular myocytesBr. J. Pharmacol.108(3)721-727(1993) 2.ChristÉ, G., Tebbakh, H., šimurdovÁ, M., et al.Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytesEur. J. Pharmacol.373(2-3)223-232(1999) 3.DelpÓn, E., Valenzuela, C.F., PÉrez, O., et al.Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating componentCirc. Res.76(2)223-235(1995) 4.Aoyama, K., Ishikuro, E., Noriduki, H., et al.Formation ratios of zearalanone, zearalenols, and zearalanols versus zearalenone during incubation of Fusarium semitectum on sorghum and ratios in naturally contaminated sorghumFood Hyg. Saf. Sci.56(6)247-251(2015) 5.Germiniani, H., and Germiniani, C.Effect of propafenone hydrochloride in ventricular arrhythmias experimentally induced by barium chlorideArq. Bras. Cardiol.36(2)101-105(1981)
| Cas No. | 1346605-05-7 | SDF | |
| 别名 | 盐酸普罗帕酮 D5 | ||
| Canonical SMILES | CCCNC([2H])([2H])C(O)([2H])C([2H])([2H])OC1=C(C=CC=C1)C(CCC2=CC=CC=C2)=O.Cl | ||
| 分子式 | C21H22D5NO3•HCl | 分子量 | 382.9 |
| 溶解度 | DMSO: soluble,Methanol: soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6116 mL | 13.0582 mL | 26.1165 mL |
| 5 mM | 0.5223 mL | 2.6116 mL | 5.2233 mL |
| 10 mM | 0.2612 mL | 1.3058 mL | 2.6116 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet