Propionyl-DL-carnitine chloride
目录号 : GC69739Propionyl-DL-carnitine chloride 是肉碱的衍生物。Propionyl-DL-carnitine chloride 可用于炎症的研究。
Cas No.:18828-58-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Propionyl-DL-carnitine chloride is a carnitine derivative. Propionyl-DL-carnitine chloride can be used for the research of inflammation[1][2][3][4].
Propionyl-DL-carnitine chloride shows protection to beta-thalassaemic erythrocytes from oxidative stress[1].
Propionyl-DL-carnitine chloride increases production of 14CO2 from [1-14C]pyruvate and increases the rate of formation of acetyl camitine from pyruvate[2].
Propionyl-DL-carnitine chloride allows the endothelial cells to maintain their functionality and regulatory role on vessel activity for a longer time and decreases the formation of oxygen reactive species due to xanthine oxidase activity on poxanthine formed by adenine nucleotide catabolism[4].
Propionyl-DL-carnitine chloride (2 mM/kg; p.o. once daily for 4 weeks) affects plasma and urine total carnitine concentrations of mice[3].
| Animal Model: | Adult age-matched male C57BL/6 mice[3] |
| Dosage: | 2 mM/kg |
| Administration: | Oral gavage; 2 mM/kg/day for 4 weeks |
| Result: | Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice. |
[1]. Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9.
[2]. Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biops Res Commun. 1994 Mar 15;199(2):949-53.
[3]. Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and psical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25.
[4]. Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during poxia. Int J Tissue React. 1991;13(1):37-40.
| Cas No. | 18828-58-5 | SDF | Download SDF |
| 分子式 | C10H20ClNO4 | 分子量 | 253.72 |
| 溶解度 | Methanol : 250 mg/mL (985.34 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.9414 mL | 19.7068 mL | 39.4135 mL |
| 5 mM | 0.7883 mL | 3.9414 mL | 7.8827 mL |
| 10 mM | 0.3941 mL | 1.9707 mL | 3.9414 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。