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Propoxycaine hydrochloride Sale

(Synonyms: 盐酸丙氧卡因;丙氧卡因盐酸盐) 目录号 : GC30957

Propoxycaine盐酸盐是一种局部麻醉剂,结合并抑制电压门控钠通道,抑制脉冲起始和传导所需的离子通量,从而导致感觉的丢失。

Propoxycaine hydrochloride Chemical Structure

Cas No.:550-83-4

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10mM (in 1mL DMSO)
¥1,188.00
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50mg
¥1,080.00
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产品描述

Propoxycaine hydrochloride is the hydrochloride salt form of Propoxycaine, a para-aminobenzoic acid ester with local anesthetic activity.Target: sodium channelPropoxycaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. This results in a loss of sensation.

Chemical Properties

Cas No. 550-83-4 SDF
别名 盐酸丙氧卡因;丙氧卡因盐酸盐
Canonical SMILES O=C(OCCN(CC)CC)C1=CC=C(N)C=C1OCCC.[H]Cl
分子式 C16H27ClN2O3 分子量 330.85
溶解度 DMSO : ≥ 83 mg/mL (250.87 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.0225 mL 15.1126 mL 30.2252 mL
5 mM 0.6045 mL 3.0225 mL 6.045 mL
10 mM 0.3023 mL 1.5113 mL 3.0225 mL
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Research Update

The effect of propoxycaine.HCl on the physical properties of neuronal membranes

Chem Phys Lipids.2008 Jul;154(1):19-25.PMID:18407836DOI: 10.1016/j.chemphyslip.2008.03.009.

Fluorescent probe techniques were used to evaluate the effect of propoxycaine.HCl on the physical properties (transbilayer asymmetric lateral and rotational mobilities, annular lipid fluidity and protein distribution) of synaptosomal plasma membrane vesicles (SPMVs) isolated from bovine cerebral cortex. An experimental procedure was used based on selective quenching of both 1,3-di(1-pyrenyl)propane (Py-3-Py) and 1,6-diphenyl-1,3,5-hexatriene (DPH) by trinitrophenyl groups, and radiationless energy transfer (RET) from the tryptophans of membrane proteins to Py-3-Py. Propoxycaine.HCl increased the bulk lateral and rotational mobilities, and annular lipid fluidity in SPMVs lipid bilayers, and had a greater fluidizing effect on the inner monolayer than that of the outer monolayer. The magnitude of increasing effect on annular lipid fluidity in SPMVs lipid bilayer induced by propoxycaine.HCl was significantly far greater than magnitude of increasing effect of the drug on the lateral and rotational mobilities of SPMVs lipid bilayer. It also caused membrane proteins to cluster. These effects of propoxycaine.HCl on neuronal membranes may be responsible for some, though not all, of the local anesthetic actions of propoxycaine.HCl.

Determination of procaine and related local anesthetics. I. Partition chromatographic separation and assay of mixtures of procaine with tetracaine and with propoxycaine

J Assoc Off Anal Chem.1975 Jan;58(1):88-92.PMID:237874

Determination of ionization and extraction constants for procaine, tetracaine, and propoxycaine led to selection of a simple partition chromatographic system for separation and assay of mixtures of these anesthetics. A 65% solution of chloroform in isooctane elutes tetracaine or propoxycaine from a pH 4:sodium bromide column; procaine is retained and subsequently eluted by chloroform as the bromide ion-pair. The anesthetics are then determined spectrophotometrically. Results of assay of standard and commercial formulations are presented.

Determination of procaine and related local anesthetics. II. Collaborative study

J Assoc Off Anal Chem.1975 Jan;58(1):93-4.PMID:1141160

The ion-pairing chromatographic method reported previously for the isolation and spectrophotometric determination of the local anesthetics, alone and in combination, was studied collaboratively. Three solutions were assayed. One containing procaine as the single active component gave an average recovery of 99.8 plus or minus 1.7%. A mixture of procaine and tetracaine gave results of 99.3 plus or minus 1.6 and 98.9 plus or minus 8.82%, respectively. A third solution containing procaine and propoxycaine assayed 100.0 plus or minus 1.5 and 99.1 plus or minus 1.9%, respectively. It was shown that low results for tetracaine were due to loss during the final evaporative step. The method for samples containing tetracaine should be studied further. The other methods have been adopted as official first action.

Effects of local anesthetics on fixed-interval responding in rhesus monkeys

Pharmacol Biochem Behav.1983 Mar;18(3):383-7.PMID:6835995DOI: 10.1016/0091-3057(83)90459-8.

Several local anesthetics of both the ester and amide type were administered IM to rhesus monkeys trained to respond on a fixed-interval 5 min schedule of food delivery. With the exception of procainamide, all local anesthetics produced dose-related decreases in response rates. Effects on pattern of responding varied between local anesthetics. With some (cocaine, dimethocaine and lidocaine), rate-dependent effects were apparent. When control rates were low, these compounds increased rates; when control rates were high, they decreased rates. However, with others (procaine, chloroprocaine, tetracaine and propoxycaine) no rate-dependent effects were noted; i.e., these compounds had little or no effect on the pattern of responding, even at doses that substantially reduced response rates. Consistent with other experiments with these compounds, cocaine was the most potent of the group. In several instances, local anesthetics which had similar stimulus properties in other behavioral paradigms differed in terms of their effects on fixed-interval behavior.