Prostaglandin A2-d4

Prostaglandin A₂-d₄ (PGA₂-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGA₂ by GC- or LC- mass spectrometry. PGA₂ is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. It has low biological potency in most bioassays, but does show some antiviral/antitumor activity.¹ At a 25 µM concentration, PGA₂ blocks the cell cycle progression of NIH 3T3 cells at the G₁ and G₂/M phase.² It has also been shown to act as a vasodilator with natriuretic properties.³

1.Fukushima, M., Kato, T., Narumiya, S., et al.Prostaglandin A and J: Antitumor and antiviral prostaglandinsAdv. Prostaglandin Thromboxane Leukot. Res.19415-418(1989) 2.Hitomi, M., Shu, J., Strom, D., et al.Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulationJ. Biol. Chem.271(16)9376-9383(1996) 3.Frolich, J.C., Sweetman, B.J., Carr, K., et al.Assessment of the levels of PGA2 in human plasma by gas chromatography-mass spectrometryProstaglandins10(1)185-195(1975)